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Fusion gene ID: 17597 |
FusionGeneSummary for INTS5_CECR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INTS5_CECR5 | Fusion gene ID: 17597 | Hgene | Tgene | Gene symbol | INTS5 | CECR5 | Gene ID | 80789 | 27440 |
| Gene name | integrator complex subunit 5 | haloacid dehalogenase like hydrolase domain containing 5 | |
| Synonyms | INT5|KIAA1698 | CECR5 | |
| Cytomap | 11q12.3 | 22q11.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integrator complex subunit 5 | haloacid dehalogenase-like hydrolase domain-containing 5cat eye syndrome chromosome region, candidate 5cat eye syndrome critical region protein 5 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6P9B9 | ||
| Ensembl transtripts involved in fusion gene | ENST00000330574, | ENST00000155674, ENST00000336737, ENST00000399852, ENST00000480451, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: INTS5 [Title/Abstract] AND CECR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INTS5 | GO:0016180 | snRNA processing | 16239144 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI037652 | INTS5 | chr11 | 62414902 | + | CECR5 | chr22 | 17619163 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000330574 | ENST00000155674 | INTS5 | chr11 | 62414902 | + | CECR5 | chr22 | 17619163 | - |
| intron-3CDS | ENST00000330574 | ENST00000336737 | INTS5 | chr11 | 62414902 | + | CECR5 | chr22 | 17619163 | - |
| intron-3CDS | ENST00000330574 | ENST00000399852 | INTS5 | chr11 | 62414902 | + | CECR5 | chr22 | 17619163 | - |
| intron-intron | ENST00000330574 | ENST00000480451 | INTS5 | chr11 | 62414902 | + | CECR5 | chr22 | 17619163 | - |
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FusionProtFeatures for INTS5_CECR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INTS5 | CECR5 |