|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 17549 |
FusionGeneSummary for INS-IGF2_RPL34 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INS-IGF2_RPL34 | Fusion gene ID: 17549 | Hgene | Tgene | Gene symbol | INS-IGF2 | RPL34 | Gene ID | 723961 | 6164 |
| Gene name | INS-IGF2 readthrough | ribosomal protein L34 | |
| Synonyms | INSIGF | L34 | |
| Cytomap | 11p15.5 | 4q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin, isoform 2INS-IGF2 readthrough transcript proteininsulin- insulin-like growth factor 2 read-through product | 60S ribosomal protein L34large ribosomal subunit protein eL34leukemia-associated protein | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | F8WCM5 | P49207 | |
| Ensembl transtripts involved in fusion gene | ENST00000481781, ENST00000397270, | ENST00000394667, ENST00000502534, ENST00000394665, ENST00000506397, ENST00000394668, | |
| Fusion gene scores | * DoF score | 22 X 31 X 1=682 | 4 X 4 X 2=32 |
| # samples | 33 | 4 | |
| ** MAII score | log2(33/682*10)=-1.04730571477836 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: INS-IGF2 [Title/Abstract] AND RPL34 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF697308 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000481781 | ENST00000394667 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000481781 | ENST00000502534 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000481781 | ENST00000394665 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000481781 | ENST00000506397 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000481781 | ENST00000394668 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000397270 | ENST00000394667 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000397270 | ENST00000502534 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000397270 | ENST00000394665 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000397270 | ENST00000506397 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
| intron-3CDS | ENST00000397270 | ENST00000394668 | INS-IGF2 | chr11 | 2153279 | - | RPL34 | chr4 | 109546339 | + |
Top |
FusionProtFeatures for INS-IGF2_RPL34 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INS-IGF2 | RPL34 |