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Fusion gene ID: 17523 |
FusionGeneSummary for INPP5E_SEC16A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INPP5E_SEC16A | Fusion gene ID: 17523 | Hgene | Tgene | Gene symbol | INPP5E | SEC16A | Gene ID | 56623 | 9919 |
| Gene name | inositol polyphosphate-5-phosphatase E | SEC16 homolog A, endoplasmic reticulum export factor | |
| Synonyms | CORS1|CPD4|JBTS1|MORMS|PPI5PIV|pharbin | KIAA0310|SEC16L|p250 | |
| Cytomap | 9q34.3 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 72 kDa inositol polyphosphate 5-phosphatasephosphatidylinositol polyphosphate 5-phosphatase type IVphosphatidylinositol-4,5-bisphosphate 5-phosphatase | protein transport protein Sec16Aprotein SEC16 homolog A | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NRR6 | O15027 | |
| Ensembl transtripts involved in fusion gene | ENST00000371712, | ENST00000313050, ENST00000467838, ENST00000371706, ENST00000313084, ENST00000290037, ENST00000431893, ENST00000398335, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 4 X 4=64 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INPP5E [Title/Abstract] AND SEC16A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SEC16A | GO:0007029 | endoplasmic reticulum organization | 21768384 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-56-6546-01A | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371712 | ENST00000313050 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000467838 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000371706 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000313084 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000290037 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000431893 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
| 5CDS-intron | ENST00000371712 | ENST00000398335 | INPP5E | chr9 | 139328489 | - | SEC16A | chr9 | 139352036 | - |
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FusionProtFeatures for INPP5E_SEC16A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INPP5E | SEC16A |