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Fusion gene ID: 17491 |
FusionGeneSummary for INO80_THSD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INO80_THSD4 | Fusion gene ID: 17491 | Hgene | Tgene | Gene symbol | INO80 | THSD4 | Gene ID | 54617 | 79875 |
| Gene name | INO80 complex subunit | thrombospondin type 1 domain containing 4 | |
| Synonyms | INO80A|INOC1|hINO80 | ADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005 | |
| Cytomap | 15q15.1 | 15q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1 | thrombospondin type-1 domain-containing protein 4A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6thrombospondin, type I, domain containing 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9ULG1 | Q6ZMP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000361937, ENST00000401393, ENST00000561244, | ENST00000355327, ENST00000261862, ENST00000357769, ENST00000567838, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 22 X 7 X 13=2002 |
| # samples | 6 | 22 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2002*10)=-3.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INO80 [Title/Abstract] AND THSD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-29-1702-01A | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000361937 | ENST00000355327 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| Frame-shift | ENST00000361937 | ENST00000261862 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| Frame-shift | ENST00000361937 | ENST00000357769 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| 5CDS-3UTR | ENST00000361937 | ENST00000567838 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| In-frame | ENST00000401393 | ENST00000355327 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| In-frame | ENST00000401393 | ENST00000261862 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| In-frame | ENST00000401393 | ENST00000357769 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| 5CDS-3UTR | ENST00000401393 | ENST00000567838 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| intron-3CDS | ENST00000561244 | ENST00000355327 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| intron-3CDS | ENST00000561244 | ENST00000261862 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| intron-3CDS | ENST00000561244 | ENST00000357769 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
| intron-3UTR | ENST00000561244 | ENST00000567838 | INO80 | chr15 | 41313098 | - | THSD4 | chr15 | 72020888 | + |
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FusionProtFeatures for INO80_THSD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INO80 | THSD4 |