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Fusion gene ID: 17472

FusionGeneSummary for INCENP_CCS

Fusion gene summary

Fusion gene information	Fusion gene name: INCENP_CCS
	Fusion gene ID: 17472
		Hgene	Tgene
	Gene symbol	INCENP	CCS
	Gene ID	3619	9973
	Gene name	inner centromere protein	copper chaperone for superoxide dismutase
	Synonyms	-	-
	Cytomap	11q12.3	11q13.2
	Type of gene	protein-coding	protein-coding
	Description	inner centromere proteinbinds and activates aurora-B and -C in vivo and in vitrochromosomal passenger proteininner centromere protein INCENPinner centromere protein antigens 135/155kDa	copper chaperone for superoxide dismutasesuperoxide dismutase copper chaperone
	Modification date	20180522	20180523
	UniProtAcc	Q9NQS7	O14618
	Ensembl transtripts involved in fusion gene	ENST00000394818, ENST00000278849, ENST00000531099,	ENST00000533244, ENST00000310190,
Fusion gene scores	* DoF score	2 X 3 X 2=12	2 X 2 X 2=8
	# samples	2	2
	** MAII score	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/8*10)=1.32192809488736
Context	PubMed: INCENP [Title/Abstract] AND CCS [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-77-8153-01A	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
TCGA	LD	LUSC	TCGA-77-8153-01A	INCENP	chr11	61908516	+	CCS	chr11	66372810	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000394818	ENST00000533244	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
In-frame	ENST00000394818	ENST00000310190	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000278849	ENST00000533244	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000278849	ENST00000310190	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000531099	ENST00000533244	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000531099	ENST00000310190	INCENP	chr11	61908983	+	CCS	chr11	66372810	+
In-frame	ENST00000394818	ENST00000533244	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
In-frame	ENST00000394818	ENST00000310190	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
In-frame	ENST00000278849	ENST00000533244	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
In-frame	ENST00000278849	ENST00000310190	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000531099	ENST00000533244	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
intron-3CDS	ENST00000531099	ENST00000310190	INCENP	chr11	61908516	+	CCS	chr11	66372810	+

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FusionProtFeatures for INCENP_CCS

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INCENP Q9NQS7	CCS O14618

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Fusion gene ID: 17472

FusionGeneSummary for INCENP_CCS

FusionProtFeatures for INCENP_CCS