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Fusion gene ID: 17361

FusionGeneSummary for IL1R1_IL1R1

Fusion gene summary

Fusion gene information	Fusion gene name: IL1R1_IL1R1
	Fusion gene ID: 17361
		Hgene	Tgene
	Gene symbol	IL1R1	IL1R1
	Gene ID	3554	3554
	Gene name	interleukin 1 receptor type 1	interleukin 1 receptor type 1
	Synonyms	CD121A\|D2S1473\|IL-1R-alpha\|IL1R\|IL1RA\|P80	CD121A\|D2S1473\|IL-1R-alpha\|IL1R\|IL1RA\|P80
	Cytomap	2q11.2-q12.1	2q11.2-q12.1
	Type of gene	protein-coding	protein-coding
	Description	interleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type I	interleukin-1 receptor type 1CD121 antigen-like family member AIL-1R-1IL-1RT-1IL-1RT1interleukin 1 receptor alpha, type Iinterleukin-1 receptor alphainterleukin-1 receptor type I
	Modification date	20180519	20180519
	UniProtAcc	P14778	P14778
	Ensembl transtripts involved in fusion gene	ENST00000424272, ENST00000409929, ENST00000409589, ENST00000409329, ENST00000409288, ENST00000410023, ENST00000233946,	ENST00000424272, ENST00000409929, ENST00000409589, ENST00000409329, ENST00000409288, ENST00000410023, ENST00000233946,
Fusion gene scores	* DoF score	3 X 6 X 5=90	4 X 5 X 2=40
	# samples	6	5
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: IL1R1 [Title/Abstract] AND IL1R1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IL1R1	GO:0070498	interleukin-1-mediated signaling pathway	10383454
Hgene	IL1R1	GO:0070555	response to interleukin-1	10383454
Tgene	IL1R1	GO:0070498	interleukin-1-mediated signaling pathway	10383454
Tgene	IL1R1	GO:0070555	response to interleukin-1	10383454

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AF054830	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
ChiTaRS3.1			BE842588	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000424272	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409929	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409589	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409329	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000409288	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000410023	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000424272	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000409929	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000409589	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000409329	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000409288	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000410023	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000233946	ENST00000233946	IL1R1	chr2	102783590	-	IL1R1	chr2	102784733	-
intron-intron	ENST00000424272	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000424272	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000424272	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000424272	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000424272	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000424272	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000424272	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409929	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409929	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409929	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409929	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409929	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409929	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409929	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000409589	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000409589	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000409589	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000409589	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000409589	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000409589	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000409589	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409329	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409329	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409329	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409329	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409329	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409329	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409329	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409288	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409288	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409288	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409288	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-intron	ENST00000409288	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409288	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
intron-3UTR	ENST00000409288	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000410023	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000410023	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000410023	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000410023	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000410023	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000410023	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000410023	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000233946	ENST00000424272	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000233946	ENST00000409929	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000233946	ENST00000409589	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000233946	ENST00000409329	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-intron	ENST00000233946	ENST00000409288	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000233946	ENST00000410023	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+
3UTR-3UTR	ENST00000233946	ENST00000233946	IL1R1	chr2	102794956	-	IL1R1	chr2	102795017	+

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FusionProtFeatures for IL1R1_IL1R1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IL1R1 P14778	IL1R1 P14778

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Fusion gene ID: 17361

FusionGeneSummary for IL1R1_IL1R1

FusionProtFeatures for IL1R1_IL1R1