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Fusion gene ID: 17207 |
FusionGeneSummary for IGFBP7_HYAL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGFBP7_HYAL2 | Fusion gene ID: 17207 | Hgene | Tgene | Gene symbol | IGFBP7 | HYAL2 | Gene ID | 3490 | 8692 |
| Gene name | insulin like growth factor binding protein 7 | hyaluronoglucosaminidase 2 | |
| Synonyms | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | LUCA2 | |
| Cytomap | 4q12 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | hyaluronidase-2PH-20 homologPH20 homologhyal-2lung carcinoma protein 2lysosomal hyaluronidase | |
| Modification date | 20180522 | 20180520 | |
| UniProtAcc | Q16270 | Q12891 | |
| Ensembl transtripts involved in fusion gene | ENST00000295666, ENST00000537922, ENST00000512512, | ENST00000447092, ENST00000357750, ENST00000395139, ENST00000442581, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/50*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: IGFBP7 [Title/Abstract] AND HYAL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
| Tgene | HYAL2 | GO:0000302 | response to reactive oxygen species | 20554532 |
| Tgene | HYAL2 | GO:0006027 | glycosaminoglycan catabolic process | 9712871 |
| Tgene | HYAL2 | GO:0009615 | response to virus | 11296287|12676986 |
| Tgene | HYAL2 | GO:0010764 | negative regulation of fibroblast migration | 19577615 |
| Tgene | HYAL2 | GO:0019064 | fusion of virus membrane with host plasma membrane | 11296287 |
| Tgene | HYAL2 | GO:0019087 | transformation of host cell by virus | 11296287 |
| Tgene | HYAL2 | GO:0030214 | hyaluronan catabolic process | 17170110|19443707|20554532|21699545 |
| Tgene | HYAL2 | GO:0030308 | negative regulation of cell growth | 18725949 |
| Tgene | HYAL2 | GO:0042117 | monocyte activation | 19443707 |
| Tgene | HYAL2 | GO:0043407 | negative regulation of MAP kinase activity | 12676986 |
| Tgene | HYAL2 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 19577615 |
| Tgene | HYAL2 | GO:0050729 | positive regulation of inflammatory response | 19443707 |
| Tgene | HYAL2 | GO:0051898 | negative regulation of protein kinase B signaling | 12676986 |
| Tgene | HYAL2 | GO:0061099 | negative regulation of protein tyrosine kinase activity | 12676986 |
| Tgene | HYAL2 | GO:0071347 | cellular response to interleukin-1 | 18390475 |
| Tgene | HYAL2 | GO:0071493 | cellular response to UV-B | 21699545 |
| Tgene | HYAL2 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 19366691 |
| Tgene | HYAL2 | GO:2000484 | positive regulation of interleukin-8 secretion | 19443707 |
| Tgene | HYAL2 | GO:2000778 | positive regulation of interleukin-6 secretion | 19443707 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF853827 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000295666 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000295666 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000537922 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000447092 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000357750 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000395139 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
| intron-3UTR | ENST00000512512 | ENST00000442581 | IGFBP7 | chr4 | 57939403 | - | HYAL2 | chr3 | 50355278 | + |
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FusionProtFeatures for IGFBP7_HYAL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGFBP7 | HYAL2 |