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Fusion gene ID: 17192 |
FusionGeneSummary for IGFBP4_INS-IGF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGFBP4_INS-IGF2 | Fusion gene ID: 17192 | Hgene | Tgene | Gene symbol | IGFBP4 | INS-IGF2 | Gene ID | 3487 | 723961 |
| Gene name | insulin like growth factor binding protein 4 | INS-IGF2 readthrough | |
| Synonyms | BP-4|HT29-IGFBP|IBP4|IGFBP-4 | INSIGF | |
| Cytomap | 17q21.2 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor-binding protein 4IBP-4IGF-binding protein 4 | insulin, isoform 2INS-IGF2 readthrough transcript proteininsulin- insulin-like growth factor 2 read-through product | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P22692 | F8WCM5 | |
| Ensembl transtripts involved in fusion gene | ENST00000542955, ENST00000269593, | ENST00000481781, ENST00000397270, | |
| Fusion gene scores | * DoF score | 5 X 7 X 2=70 | 14 X 23 X 1=322 |
| # samples | 7 | 24 | |
| ** MAII score | log2(7/70*10)=0 | log2(24/322*10)=-0.424026282506098 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IGFBP4 [Title/Abstract] AND INS-IGF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI051493 | IGFBP4 | chr17 | 38613149 | + | INS-IGF2 | chr11 | 2153404 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000542955 | ENST00000481781 | IGFBP4 | chr17 | 38613149 | + | INS-IGF2 | chr11 | 2153404 | - |
| 3UTR-intron | ENST00000542955 | ENST00000397270 | IGFBP4 | chr17 | 38613149 | + | INS-IGF2 | chr11 | 2153404 | - |
| 3UTR-intron | ENST00000269593 | ENST00000481781 | IGFBP4 | chr17 | 38613149 | + | INS-IGF2 | chr11 | 2153404 | - |
| 3UTR-intron | ENST00000269593 | ENST00000397270 | IGFBP4 | chr17 | 38613149 | + | INS-IGF2 | chr11 | 2153404 | - |
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FusionProtFeatures for IGFBP4_INS-IGF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGFBP4 | INS-IGF2 |