|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 17178 |
FusionGeneSummary for IGF2_SNW1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGF2_SNW1 | Fusion gene ID: 17178 | Hgene | Tgene | Gene symbol | IGF2 | SNW1 | Gene ID | 3481 | 22938 |
| Gene name | insulin like growth factor 2 | SNW domain containing 1 | |
| Synonyms | C11orf43|GRDF|IGF-II|PP9974 | Bx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1 | |
| Cytomap | 11p15.5 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin | SNW domain-containing protein 1SKI interacting proteinhomolog of Drosophila BX42nuclear protein SkiPnuclear receptor coactivator NCoA-62nuclear receptor coactivator, 62-kDski-interacting protein | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P01344 | Q13573 | |
| Ensembl transtripts involved in fusion gene | ENST00000381395, ENST00000381406, ENST00000416167, ENST00000300632, ENST00000434045, ENST00000381392, ENST00000381389, ENST00000418738, | ENST00000261531, ENST00000554775, ENST00000555761, | |
| Fusion gene scores | * DoF score | 10 X 5 X 8=400 | 15 X 4 X 12=720 |
| # samples | 12 | 16 | |
| ** MAII score | log2(12/400*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/720*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IGF2 [Title/Abstract] AND SNW1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IGF2 | GO:0008284 | positive regulation of cell proliferation | 28873464 |
| Hgene | IGF2 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
| Hgene | IGF2 | GO:0043410 | positive regulation of MAPK cascade | 11500939 |
| Hgene | IGF2 | GO:0045840 | positive regulation of mitotic nuclear division | 11500939 |
| Hgene | IGF2 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 11500939 |
| Hgene | IGF2 | GO:0051897 | positive regulation of protein kinase B signaling | 11500939 |
| Tgene | SNW1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14985122 |
| Tgene | SNW1 | GO:0000398 | mRNA splicing, via spliceosome | 15194481|28076346 |
| Tgene | SNW1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 11278756 |
| Tgene | SNW1 | GO:0043923 | positive regulation by host of viral transcription | 15905409 |
| Tgene | SNW1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10713164|15878163 |
| Tgene | SNW1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14985122|19934264 |
| Tgene | SNW1 | GO:0048384 | retinoic acid receptor signaling pathway | 19934264 |
| Tgene | SNW1 | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 14985122 |
| Tgene | SNW1 | GO:0070562 | regulation of vitamin D receptor signaling pathway | 14985122 |
| Tgene | SNW1 | GO:0070564 | positive regulation of vitamin D receptor signaling pathway | 9632709|11514567 |
| Tgene | SNW1 | GO:0071300 | cellular response to retinoic acid | 19934264 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | THCA | TCGA-BJ-A291-01A | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000381395 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381395 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381395 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381406 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381406 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381406 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000416167 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000416167 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000416167 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| 5CDS-intron | ENST00000300632 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| 5CDS-intron | ENST00000300632 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| 5CDS-intron | ENST00000300632 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000434045 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000434045 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000434045 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381392 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381392 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381392 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381389 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381389 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000381389 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000418738 | ENST00000261531 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000418738 | ENST00000554775 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
| intron-intron | ENST00000418738 | ENST00000555761 | IGF2 | chr11 | 2150348 | - | SNW1 | chr14 | 78189203 | - |
Top |
FusionProtFeatures for IGF2_SNW1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGF2 | SNW1 |