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Fusion gene ID: 17145

FusionGeneSummary for IGF1R_PRPS1

Fusion gene summary

Fusion gene information	Fusion gene name: IGF1R_PRPS1
	Fusion gene ID: 17145
		Hgene	Tgene
	Gene symbol	IGF1R	PRPS1
	Gene ID	3480	5631
	Gene name	insulin like growth factor 1 receptor	phosphoribosyl pyrophosphate synthetase 1
	Synonyms	CD221\|IGFIR\|IGFR\|JTK13	ARTS\|CMTX5\|DFN2\|DFNX1\|PPRibP\|PRS-I\|PRSI
	Cytomap	15q26.3	Xq22.3
	Type of gene	protein-coding	protein-coding
	Description	insulin-like growth factor 1 receptorIGF-I receptorsoluble IGF1R variant 1soluble IGF1R variant 2	ribose-phosphate pyrophosphokinase 1dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1)deafness 2, perceptive, congenitaldeafness, X-linked 2, perceptive, congenitalphosphoribosyl pyrophosphate synthase Iribose-phosphate diphosphokinase 1
	Modification date	20180527	20180523
	UniProtAcc	P08069	P60891
	Ensembl transtripts involved in fusion gene	ENST00000268035, ENST00000558762, ENST00000560432,	ENST00000372435, ENST00000372428, ENST00000372419, ENST00000543248, ENST00000372418,
Fusion gene scores	* DoF score	11 X 8 X 3=264	2 X 1 X 2=4
	# samples	11	2
	** MAII score	log2(11/264*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: IGF1R [Title/Abstract] AND PRPS1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IGF1R	GO:0043066	negative regulation of apoptotic process	12556535
Hgene	IGF1R	GO:0046328	regulation of JNK cascade	12556535
Hgene	IGF1R	GO:0046777	protein autophosphorylation	1846292\|7679099\|11162456
Hgene	IGF1R	GO:0048009	insulin-like growth factor receptor signaling pathway	7679099
Hgene	IGF1R	GO:0048015	phosphatidylinositol-mediated signaling	7692086
Hgene	IGF1R	GO:0051262	protein tetramerization	1846292
Hgene	IGF1R	GO:0051389	inactivation of MAPKK activity	12556535

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-A8-A09E-01A	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000268035	ENST00000372435	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000268035	ENST00000372428	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000268035	ENST00000372419	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000268035	ENST00000543248	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-intron	ENST00000268035	ENST00000372418	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
In-frame	ENST00000558762	ENST00000372435	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000558762	ENST00000372428	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000558762	ENST00000372419	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-5UTR	ENST00000558762	ENST00000543248	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
5CDS-intron	ENST00000558762	ENST00000372418	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
intron-3CDS	ENST00000560432	ENST00000372435	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
intron-5UTR	ENST00000560432	ENST00000372428	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
intron-5UTR	ENST00000560432	ENST00000372419	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
intron-5UTR	ENST00000560432	ENST00000543248	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+
intron-intron	ENST00000560432	ENST00000372418	IGF1R	chr15	99486281	+	PRPS1	chrX	106882525	+

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FusionProtFeatures for IGF1R_PRPS1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IGF1R P08069	PRPS1 P60891

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Fusion gene ID: 17145

FusionGeneSummary for IGF1R_PRPS1

FusionProtFeatures for IGF1R_PRPS1