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Fusion gene ID: 17133 |
FusionGeneSummary for IGDCC3_GLDN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGDCC3_GLDN | Fusion gene ID: 17133 | Hgene | Tgene | Gene symbol | IGDCC3 | GLDN | Gene ID | 9543 | 342035 |
| Gene name | immunoglobulin superfamily DCC subclass member 3 | gliomedin | |
| Synonyms | HsT18880|PUNC | CLOM|COLM|CRG-L2|CRGL2|LCCS11|UNC-112 | |
| Cytomap | 15q22.31 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | immunoglobulin superfamily DCC subclass member 3putative neuronal cell adhesion molecule | gliomedincollomincolmedin | |
| Modification date | 20180331 | 20180415 | |
| UniProtAcc | Q8IVU1 | Q6ZMI3 | |
| Ensembl transtripts involved in fusion gene | ENST00000327987, ENST00000559231, | ENST00000335449, ENST00000396399, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: IGDCC3 [Title/Abstract] AND GLDN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DB-5277-01A | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000327987 | ENST00000335449 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| In-frame | ENST00000327987 | ENST00000396399 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| intron-3CDS | ENST00000559231 | ENST00000335449 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
| intron-3CDS | ENST00000559231 | ENST00000396399 | IGDCC3 | chr15 | 65667435 | - | GLDN | chr15 | 51675982 | + |
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FusionProtFeatures for IGDCC3_GLDN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGDCC3 | GLDN |