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Fusion gene ID: 17057 |
FusionGeneSummary for IFI27_IFI27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFI27_IFI27 | Fusion gene ID: 17057 | Hgene | Tgene | Gene symbol | IFI27 | IFI27 | Gene ID | 3429 | 3429 |
| Gene name | interferon alpha inducible protein 27 | interferon alpha inducible protein 27 | |
| Synonyms | FAM14D|ISG12|ISG12A|P27 | FAM14D|ISG12|ISG12A|P27 | |
| Cytomap | 14q32.12 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon alpha-inducible protein 27, mitochondrial2310061N23RikISG12(a)interferon alpha-induced 11.5 kDa proteininterferon-stimulated gene 12a protein | interferon alpha-inducible protein 27, mitochondrial2310061N23RikISG12(a)interferon alpha-induced 11.5 kDa proteininterferon-stimulated gene 12a protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P40305 | P40305 | |
| Ensembl transtripts involved in fusion gene | ENST00000444961, ENST00000448882, ENST00000557098, ENST00000298902, ENST00000557634, ENST00000555744, | ENST00000444961, ENST00000448882, ENST00000557098, ENST00000298902, ENST00000557634, ENST00000555744, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: IFI27 [Title/Abstract] AND IFI27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IFI27 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18330707 |
| Hgene | IFI27 | GO:0097190 | apoptotic signaling pathway | 18330707 |
| Tgene | IFI27 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18330707 |
| Tgene | IFI27 | GO:0097190 | apoptotic signaling pathway | 18330707 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG230457 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000444961 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000444961 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000444961 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000444961 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000444961 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000444961 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000448882 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000448882 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000448882 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000448882 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000448882 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000448882 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000557098 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000557098 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000557098 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000557098 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000557098 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000557098 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| Frame-shift | ENST00000298902 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| Frame-shift | ENST00000298902 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000298902 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000298902 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000298902 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000298902 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000557634 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| In-frame | ENST00000557634 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000557634 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000557634 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000557634 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000557634 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| Frame-shift | ENST00000555744 | ENST00000444961 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| Frame-shift | ENST00000555744 | ENST00000448882 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000555744 | ENST00000557098 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-5UTR | ENST00000555744 | ENST00000298902 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000555744 | ENST00000557634 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
| 5CDS-intron | ENST00000555744 | ENST00000555744 | IFI27 | chr14 | 94582861 | + | IFI27 | chr14 | 94581206 | + |
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FusionProtFeatures for IFI27_IFI27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFI27 | IFI27 |