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Fusion gene ID: 16993

FusionGeneSummary for IARS_SLC10A7

Fusion gene summary

Fusion gene information	Fusion gene name: IARS_SLC10A7
	Fusion gene ID: 16993
		Hgene	Tgene
	Gene symbol	IARS	SLC10A7
	Gene ID	3376	84068
	Gene name	isoleucyl-tRNA synthetase	solute carrier family 10 member 7
	Synonyms	GRIDHH\|IARS1\|ILERS\|ILRS\|IRS\|PRO0785	C4orf13\|P7
	Cytomap	9q22.31	4q31.22
	Type of gene	protein-coding	protein-coding
	Description	isoleucine--tRNA ligase, cytoplasmicisoleucine tRNA ligase 1, cytoplasmic	sodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7
	Modification date	20180523	20180519
	UniProtAcc	P41252	Q0GE19
	Ensembl transtripts involved in fusion gene	ENST00000375643, ENST00000375629, ENST00000443024, ENST00000447699, ENST00000375627, ENST00000474340,	ENST00000432059, ENST00000335472, ENST00000264986, ENST00000507030, ENST00000394062, ENST00000394059, ENST00000511315, ENST00000511374, ENST00000502607,
Fusion gene scores	* DoF score	7 X 9 X 2=126	2 X 2 X 2=8
	# samples	11	2
	** MAII score	log2(11/126*10)=-0.195920209975257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: IARS [Title/Abstract] AND SLC10A7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IARS	GO:0006428	isoleucyl-tRNA aminoacylation	8052601

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			W52666	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000375643	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375643	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375629	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000443024	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000447699	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000375627	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000432059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000335472	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000264986	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000507030	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000394062	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000394059	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000511315	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000511374	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+
intron-intron	ENST00000474340	ENST00000502607	IARS	chr9	95019084	+	SLC10A7	chr4	147187380	+

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FusionProtFeatures for IARS_SLC10A7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IARS P41252	SLC10A7 Q0GE19

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Fusion gene ID: 16993

FusionGeneSummary for IARS_SLC10A7

FusionProtFeatures for IARS_SLC10A7