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Fusion gene ID: 1698 |
FusionGeneSummary for ANKFN1_PRR11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKFN1_PRR11 | Fusion gene ID: 1698 | Hgene | Tgene | Gene symbol | ANKFN1 | PRR11 | Gene ID | 162282 | 55771 |
| Gene name | ankyrin repeat and fibronectin type III domain containing 1 | proline rich 11 | |
| Synonyms | - | - | |
| Cytomap | 17q22 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and fibronectin type-III domain-containing protein 1 | proline-rich protein 11transcription repressor of MHCII | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q8N957 | Q96HE9 | |
| Ensembl transtripts involved in fusion gene | ENST00000318698, ENST00000566473, ENST00000574292, | ENST00000262293, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 1 X 4=24 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ANKFN1 [Title/Abstract] AND PRR11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRR11 | GO:0051726 | regulation of cell cycle | 23246489 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-QC-A6FX-01A | ANKFN1 | chr17 | 54576459 | + | PRR11 | chr17 | 57247109 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000318698 | ENST00000262293 | ANKFN1 | chr17 | 54576459 | + | PRR11 | chr17 | 57247109 | + |
| 5CDS-5UTR | ENST00000566473 | ENST00000262293 | ANKFN1 | chr17 | 54576459 | + | PRR11 | chr17 | 57247109 | + |
| intron-5UTR | ENST00000574292 | ENST00000262293 | ANKFN1 | chr17 | 54576459 | + | PRR11 | chr17 | 57247109 | + |
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FusionProtFeatures for ANKFN1_PRR11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKFN1 | PRR11 |