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Fusion gene ID: 16969 |
FusionGeneSummary for HVCN1_CPM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HVCN1_CPM | Fusion gene ID: 16969 | Hgene | Tgene | Gene symbol | HVCN1 | CPM | Gene ID | 84329 | 1368 |
| Gene name | hydrogen voltage gated channel 1 | carboxypeptidase M | |
| Synonyms | HV1|VSOP | - | |
| Cytomap | 12q24.11 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-gated hydrogen channel 1voltage sensor domain-only protein | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96D96 | P14384 | |
| Ensembl transtripts involved in fusion gene | ENST00000548312, ENST00000242607, ENST00000356742, ENST00000439744, | ENST00000546373, ENST00000551568, ENST00000338356, ENST00000549691, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 38 X 10 X 8=3040 |
| # samples | 2 | 35 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(35/3040*10)=-3.11864449649862 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HVCN1 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HVCN1 | GO:0010043 | response to zinc ion | 16554753 |
| Hgene | HVCN1 | GO:0071294 | cellular response to zinc ion | 22020278 |
| Hgene | HVCN1 | GO:0071467 | cellular response to pH | 22020278 |
| Hgene | HVCN1 | GO:1902600 | proton transmembrane transport | 22020278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A23Y-01A | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000548312 | ENST00000546373 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000548312 | ENST00000551568 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000548312 | ENST00000338356 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-intron | ENST00000548312 | ENST00000549691 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000242607 | ENST00000546373 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000242607 | ENST00000551568 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000242607 | ENST00000338356 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-intron | ENST00000242607 | ENST00000549691 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| intron-3CDS | ENST00000356742 | ENST00000546373 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| intron-3CDS | ENST00000356742 | ENST00000551568 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| intron-3CDS | ENST00000356742 | ENST00000338356 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| intron-intron | ENST00000356742 | ENST00000549691 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000439744 | ENST00000546373 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000439744 | ENST00000551568 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-3CDS | ENST00000439744 | ENST00000338356 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
| 5UTR-intron | ENST00000439744 | ENST00000549691 | HVCN1 | chr12 | 111126430 | - | CPM | chr12 | 69279669 | - |
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FusionProtFeatures for HVCN1_CPM |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HVCN1 | CPM |