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Fusion gene ID: 1695 |
FusionGeneSummary for ANKDD1A_PLEKHO2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKDD1A_PLEKHO2 | Fusion gene ID: 1695 | Hgene | Tgene | Gene symbol | ANKDD1A | PLEKHO2 | Gene ID | 348094 | 80301 |
| Gene name | ankyrin repeat and death domain containing 1A | pleckstrin homology domain containing O2 | |
| Synonyms | - | PLEKHQ1|PP1628|pp9099 | |
| Cytomap | 15q22.31 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and death domain-containing protein 1A | pleckstrin homology domain-containing family O member 2PH domain-containing family O member 2PH domain-containing family Q member 1PH domain-containing proteinpleckstrin homology domain-containing family Q member 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q495B1 | Q8TD55 | |
| Ensembl transtripts involved in fusion gene | ENST00000491145, ENST00000395720, ENST00000357698, ENST00000380230, ENST00000496660, ENST00000319580, ENST00000395723, | ENST00000323544, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANKDD1A [Title/Abstract] AND PLEKHO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0152-02A | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000491145 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| In-frame | ENST00000395720 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| In-frame | ENST00000357698 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| In-frame | ENST00000380230 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| intron-3CDS | ENST00000496660 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| intron-3CDS | ENST00000319580 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
| In-frame | ENST00000395723 | ENST00000323544 | ANKDD1A | chr15 | 65234762 | + | PLEKHO2 | chr15 | 65152093 | + |
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FusionProtFeatures for ANKDD1A_PLEKHO2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKDD1A | PLEKHO2 |