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Fusion gene ID: 16937 |
FusionGeneSummary for HTN3_OSBPL1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HTN3_OSBPL1A | Fusion gene ID: 16937 | Hgene | Tgene | Gene symbol | HTN3 | OSBPL1A | Gene ID | 3347 | 114876 |
| Gene name | histatin 3 | oxysterol binding protein like 1A | |
| Synonyms | HIS2|HTN2|HTN5 | ORP-1|ORP1|OSBPL1B | |
| Cytomap | 4q13.3 | 18q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst | oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P15516 | Q9BXW6 | |
| Ensembl transtripts involved in fusion gene | ENST00000526767, ENST00000530128, ENST00000381057, | ENST00000319481, ENST00000399443, ENST00000357041, ENST00000399441, ENST00000582618, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 11 X 9 X 9=891 |
| # samples | 3 | 12 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/891*10)=-2.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HTN3 [Title/Abstract] AND OSBPL1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP334921 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000526767 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-3CDS | ENST00000526767 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-3CDS | ENST00000526767 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-intron | ENST00000526767 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-intron | ENST00000526767 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| intron-3CDS | ENST00000530128 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| intron-3CDS | ENST00000530128 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| intron-3CDS | ENST00000530128 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| intron-intron | ENST00000530128 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| intron-intron | ENST00000530128 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-3CDS | ENST00000381057 | ENST00000319481 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-3CDS | ENST00000381057 | ENST00000399443 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-3CDS | ENST00000381057 | ENST00000357041 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-intron | ENST00000381057 | ENST00000399441 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
| 3UTR-intron | ENST00000381057 | ENST00000582618 | HTN3 | chr4 | 70902122 | + | OSBPL1A | chr18 | 21776127 | - |
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FusionProtFeatures for HTN3_OSBPL1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HTN3 | OSBPL1A |