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Fusion gene ID: 16931

FusionGeneSummary for HSPH1_PLEKHA5

Fusion gene summary

Fusion gene information	Fusion gene name: HSPH1_PLEKHA5
	Fusion gene ID: 16931
		Hgene	Tgene
	Gene symbol	HSPH1	PLEKHA5
	Gene ID	10808	54477
	Gene name	heat shock protein family H (Hsp110) member 1	pleckstrin homology domain containing A5
	Synonyms	HSP105\|HSP105A\|HSP105B\|NY-CO-25	PEPP-2\|PEPP2
	Cytomap	13q12.3	12p12.3
	Type of gene	protein-coding	protein-coding
	Description	heat shock protein 105 kDaantigen NY-CO-25heat shock 105kDa/110kDa protein 1	pleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5
	Modification date	20180523	20180519
	UniProtAcc	Q92598	Q9HAU0
	Ensembl transtripts involved in fusion gene	ENST00000380406, ENST00000380405, ENST00000320027, ENST00000445273, ENST00000429785,	ENST00000309364, ENST00000359180, ENST00000317589, ENST00000355397, ENST00000429027, ENST00000539256, ENST00000299275, ENST00000538714, ENST00000543806, ENST00000424268, ENST00000540972, ENST00000510738,
Fusion gene scores	* DoF score	3 X 2 X 3=18	21 X 8 X 13=2184
	# samples	3	22
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(22/2184*10)=-3.31139742739519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HSPH1 [Title/Abstract] AND PLEKHA5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	HNSC	TCGA-CR-6474-01A	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000380406	ENST00000309364	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000359180	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000317589	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000355397	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000429027	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000539256	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000299275	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000538714	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000543806	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000424268	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000540972	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380406	ENST00000510738	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000309364	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000359180	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000317589	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000355397	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000429027	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000539256	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000299275	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000538714	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000543806	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000424268	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000540972	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000380405	ENST00000510738	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000309364	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000359180	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000317589	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000355397	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000429027	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000539256	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000299275	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000538714	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000543806	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000424268	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000540972	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
5CDS-intron	ENST00000320027	ENST00000510738	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000309364	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000359180	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000317589	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000355397	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000429027	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000539256	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000299275	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000538714	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000543806	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000424268	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000540972	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000445273	ENST00000510738	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000309364	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000359180	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000317589	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000355397	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000429027	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000539256	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000299275	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000538714	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000543806	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000424268	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000540972	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+
intron-intron	ENST00000429785	ENST00000510738	HSPH1	chr13	31710765	-	PLEKHA5	chr12	19441012	+

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FusionProtFeatures for HSPH1_PLEKHA5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSPH1 Q92598	PLEKHA5 Q9HAU0

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Fusion gene ID: 16931

FusionGeneSummary for HSPH1_PLEKHA5

FusionProtFeatures for HSPH1_PLEKHA5