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Fusion gene ID: 1692

FusionGeneSummary for ANKAR_MFSD6

Fusion gene summary

Fusion gene information	Fusion gene name: ANKAR_MFSD6
	Fusion gene ID: 1692
		Hgene	Tgene
	Gene symbol	ANKAR	MFSD6
	Gene ID	150709	54842
	Gene name	ankyrin and armadillo repeat containing	major facilitator superfamily domain containing 6
	Synonyms	-	MMR2\|hMMR2
	Cytomap	2q32.2	2q32.2
	Type of gene	protein-coding	protein-coding
	Description	ankyrin and armadillo repeat-containing protein	major facilitator superfamily domain-containing protein 6macrophage MHC class I receptor 2 homologmacrophage MHC receptor 2
	Modification date	20180522	20180329
	UniProtAcc	Q7Z5J8	Q6ZSS7
	Ensembl transtripts involved in fusion gene	ENST00000520309, ENST00000313581, ENST00000281412, ENST00000438402, ENST00000431575, ENST00000461516,	ENST00000392328, ENST00000281416, ENST00000535751, ENST00000489793,
Fusion gene scores	* DoF score	3 X 2 X 3=18	3 X 2 X 3=18
	# samples	3	3
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ANKAR [Title/Abstract] AND MFSD6 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LIHC	TCGA-DD-A1EL-01A	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000520309	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000520309	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000520309	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
5CDS-intron	ENST00000520309	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000313581	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000313581	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000313581	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
5CDS-intron	ENST00000313581	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000281412	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000281412	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000281412	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
5CDS-intron	ENST00000281412	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000438402	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000438402	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000438402	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
5CDS-intron	ENST00000438402	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000431575	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000431575	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
In-frame	ENST00000431575	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
5CDS-intron	ENST00000431575	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
intron-3CDS	ENST00000461516	ENST00000392328	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
intron-3CDS	ENST00000461516	ENST00000281416	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
intron-3CDS	ENST00000461516	ENST00000535751	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+
intron-intron	ENST00000461516	ENST00000489793	ANKAR	chr2	190561095	+	MFSD6	chr2	191353383	+

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FusionProtFeatures for ANKAR_MFSD6

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANKAR Q7Z5J8	MFSD6 Q6ZSS7

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Fusion gene ID: 1692

FusionGeneSummary for ANKAR_MFSD6

FusionProtFeatures for ANKAR_MFSD6