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Fusion gene ID: 16899 |
FusionGeneSummary for HSPB1_STAT6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSPB1_STAT6 | Fusion gene ID: 16899 | Hgene | Tgene | Gene symbol | HSPB1 | STAT6 | Gene ID | 3315 | 6778 |
| Gene name | heat shock protein family B (small) member 1 | signal transducer and activator of transcription 6 | |
| Synonyms | CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27 | D12S1644|IL-4-STAT|STAT6B|STAT6C | |
| Cytomap | 7q11.23 | 12q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heat shock protein beta-128 kDa heat shock proteinepididymis secretory protein Li 102estrogen-regulated 24 kDa proteinheat shock 27 kDa proteinheat shock 27kD protein 1heat shock 27kDa protein 1stress-responsive protein 27 | signal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P04792 | P42226 | |
| Ensembl transtripts involved in fusion gene | ENST00000248553, ENST00000429938, | ENST00000300134, ENST00000538913, ENST00000543873, ENST00000556155, ENST00000537215, ENST00000454075, | |
| Fusion gene scores | * DoF score | 20 X 13 X 6=1560 | 37 X 8 X 15=4440 |
| # samples | 21 | 43 | |
| ** MAII score | log2(21/1560*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(43/4440*10)=-3.36815111164801 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HSPB1 [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STAT6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8810328 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-VS-A958-01A | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000248553 | ENST00000300134 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000248553 | ENST00000538913 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000248553 | ENST00000543873 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000248553 | ENST00000556155 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000248553 | ENST00000537215 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000248553 | ENST00000454075 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000300134 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000538913 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000543873 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000556155 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000537215 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
| 5CDS-intron | ENST00000429938 | ENST00000454075 | HSPB1 | chr7 | 75933612 | + | STAT6 | chr12 | 57496773 | - |
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FusionProtFeatures for HSPB1_STAT6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSPB1 | STAT6 |