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Fusion gene ID: 16824 |
FusionGeneSummary for HSP90AA1_ARHGAP32 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HSP90AA1_ARHGAP32 | Fusion gene ID: 16824 | Hgene | Tgene | Gene symbol | HSP90AA1 | ARHGAP32 | Gene ID | 3320 | 9743 |
| Gene name | heat shock protein 90 alpha family class A member 1 | Rho GTPase activating protein 32 | |
| Synonyms | EL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2 | GC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAP | |
| Cytomap | 14q32.31 | 11q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock | rho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P07900 | A7KAX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000216281, ENST00000334701, ENST00000441629, ENST00000558600, | ENST00000310343, ENST00000524655, ENST00000392657, ENST00000527272, | |
| Fusion gene scores | * DoF score | 15 X 16 X 3=720 | 3 X 2 X 2=12 |
| # samples | 17 | 3 | |
| ** MAII score | log2(17/720*10)=-2.08246216019197 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HSP90AA1 [Title/Abstract] AND ARHGAP32 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HSP90AA1 | GO:0001934 | positive regulation of protein phosphorylation | 19363271 |
| Hgene | HSP90AA1 | GO:0007004 | telomere maintenance via telomerase | 10197982 |
| Hgene | HSP90AA1 | GO:0031396 | regulation of protein ubiquitination | 16809764 |
| Hgene | HSP90AA1 | GO:0032273 | positive regulation of protein polymerization | 19363271 |
| Hgene | HSP90AA1 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Hgene | HSP90AA1 | GO:0051131 | chaperone-mediated protein complex assembly | 15644312 |
| Hgene | HSP90AA1 | GO:0051973 | positive regulation of telomerase activity | 10197982 |
| Hgene | HSP90AA1 | GO:1902949 | positive regulation of tau-protein kinase activity | 19363271 |
| Hgene | HSP90AA1 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP224230 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000216281 | ENST00000310343 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000216281 | ENST00000524655 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000216281 | ENST00000392657 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000216281 | ENST00000527272 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3CDS | ENST00000334701 | ENST00000310343 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000334701 | ENST00000524655 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000334701 | ENST00000392657 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000334701 | ENST00000527272 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3CDS | ENST00000441629 | ENST00000310343 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000441629 | ENST00000524655 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000441629 | ENST00000392657 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000441629 | ENST00000527272 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3CDS | ENST00000558600 | ENST00000310343 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000558600 | ENST00000524655 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000558600 | ENST00000392657 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
| intron-3UTR | ENST00000558600 | ENST00000527272 | HSP90AA1 | chr14 | 102548114 | - | ARHGAP32 | chr11 | 128840969 | - |
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FusionProtFeatures for HSP90AA1_ARHGAP32 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HSP90AA1 | ARHGAP32 |