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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 16795

FusionGeneSummary for HSD11B1L_SAFB

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD11B1L_SAFB
Fusion gene ID: 16795
HgeneTgene
Gene symbol

HSD11B1L

SAFB

Gene ID

374875

6294

Gene namehydroxysteroid 11-beta dehydrogenase 1 likescaffold attachment factor B
Synonyms11-DH3|11-beta-HSD3|HSD3|SCDR10|SCDR10B|SDR26C2HAP|HET|SAB-B1|SAF-B|SAF-B1|SAFB1
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionhydroxysteroid 11-beta-dehydrogenase 1-like protein11-beta-hydroxysteroid dehydrogenase type 3short chain dehydrogenase/reductase 10short chain dehydrogenase/reductase family 26C member 2scaffold attachment factor B1HSP27 ERE-TATA-binding proteinHSP27 estrogen response element-TATA box-binding proteinHsp27 ERE-TATA binding proteinglutathione S-transferase fusion proteinheat-shock protein (HSP27) estrogen response element and TATA box
Modification date2018051920180523
UniProtAcc

Q7Z5J1

Q15424

Ensembl transtripts involved in fusion geneENST00000577917, ENST00000581893, 
ENST00000411793, ENST00000301382, 
ENST00000581773, ENST00000423665, 
ENST00000583928, ENST00000342970, 
ENST00000422535, ENST00000577701, 
ENST00000581521, ENST00000339423, 
ENST00000292123, ENST00000592224, 
ENST00000586934, ENST00000454510, 
ENST00000433404, ENST00000588852, 
ENST00000538656, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSD11B1L [Title/Abstract] AND SAFB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7374-01AHSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000577917ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000577917ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000577917ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581893ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581893ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581893ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000411793ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000411793ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000411793ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000301382ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000301382ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000301382ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581773ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581773ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581773ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000423665ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000423665ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000423665ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000583928ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000583928ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000583928ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000342970ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000342970ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000342970ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000422535ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000422535ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000422535ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000577701ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-3CDSENST00000577701ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
intron-intronENST00000577701ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581521ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000581521ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000581521ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000339423ENST00000292123HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
In-frameENST00000339423ENST00000592224HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000586934HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000454510HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000433404HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000588852HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+
5CDS-intronENST00000339423ENST00000538656HSD11B1Lchr19

5687679

+SAFBchr19

5664033

+

Top

FusionProtFeatures for HSD11B1L_SAFB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD11B1L

Q7Z5J1

SAFB

Q15424

Binds to scaffold/matrix attachment region (S/MAR) DNAand forms a molecular assembly point to allow the formation of a'transcriptosomal' complex (consisting of SR proteins and RNApolymerase II) coupling transcription and RNA processing (Bysimilarity). Can function as an estrogen receptor corepressor andcan also bind to the HSP27 promoter and decrease itstranscription. When associated with RBMX, binds to and stimulatestranscription from the SREBF1 promoter (By similarity). Caninhibit cell proliferation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56114_116141206Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+5636_62141206Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+5687_88141206Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78114_116222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78178_182222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+78211_217222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+7836_62222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000339423+7887_88222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67114_116135200Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+6736_62135200Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+6787_88135200Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+5636_6288182Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+5687_8888182Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78114_116222316Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78178_182222316Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+78211_217222316Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+7836_62222316Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000423665+7887_88222316Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56114_116141235Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+5636_62141235Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+5687_88141235Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910114_116222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910178_182222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+910211_217222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+91036_62222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581521+91087_88222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89114_116222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89178_182222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+89211_217222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+8936_62222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581773+8987_88222287Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+5636_6288153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+5687_8888153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+4536_6288153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+4587_8888153Nucleotide bindingNADP
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421785_903717916Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320785_903648849Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421785_903717918Compositional biasNote=Gly-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421785_903716917Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56178_182141206Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000301382+56211_217141206Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67178_182135200Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000342970+67211_217135200Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56114_11688182Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56178_18288182Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000411793+56211_21788182Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14114_116-8088Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14178_182-8088Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+14211_217-8088Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+1436_62-8088Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000422535+1487_88-8088Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56178_182141235Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000577917+56211_217141235Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56114_11688153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56178_18288153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000581893+56211_21788153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45114_11688153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45178_18288153Nucleotide bindingNADP
HgeneHSD11B1Lchr19:5687679chr19:5664033ENST00000583928+45211_21788153Nucleotide bindingNADP
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421612_831717916Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421625_705717916Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320612_831648849Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320625_705648849Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421612_831717918Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421625_705717918Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421612_831716917Compositional biasNote=Arg-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421625_705716917Compositional biasNote=Glu-rich
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+142131_65717916DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421406_484717916DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+132031_65648849DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320406_484648849DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+142131_65717918DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421406_484717918DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+142131_65716917DomainSAP
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421406_484716917DomainRRM
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421599_616717916MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320599_616648849MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421599_616717918MotifNuclear localization signal
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421599_616716917MotifNuclear localization signal


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FusionGeneSequence for HSD11B1L_SAFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HSD11B1L_SAFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HSD11B1LCOPS5SAFBSAFB2, ABHD16A, TAF15, ESR1, CHD1, CLK1, CHD3, HNRNPD, HNRNPA1, USP45, KHDRBS2, RB1CC1, NCOR1, HDAC3, SRRM1, MAP1LC3B, CDC37, PIAS1, SREK1, ELAVL1, TCF3, CUL3, SAP18, SMU1, TPBG, TRIM55, U2AF1, RBMX, SON, TRMT112, SEPT7, UTP14A, VTN, ZC3H18, USP39, TMOD2, VASN, SRSF7, LAMP2, EPPK1, PRKAR1A, CORO1B, GCN1L1, AK2, CPSF6, NCSTN, ACAT1, U2AF2, ACIN1, ABCC1, SURF4, DYNLRB1, TP53BP1, CSNK2A1, TP63, IL7R, MAP1LC3A, LGR4, STAU1, CUL7, OBSL1, EED, SRPK1, TP53, ABCE1, ZFP41, UNK, NTRK1, HNRNPU, HNRNPUL1, MCM4, P4HB, SF3B6, EWSR1, SRPK2, PPP1CB, MATR3, MPHOSPH8, ELAVL2, CAPN13, APOBEC3D, CDK1, COQ2, COX15, DLST, DNM1L, PDHA1, VDAC1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421528_792717916POLR2A
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320528_792648849POLR2A
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421528_792717918POLR2A
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421528_792716917POLR2A
TgeneSAFBchr19:5687679chr19:5664033ENST00000292123+1421599_915717916SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST00000454510+1320599_915648849SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST00000588852+1421599_915717918SAFB2
TgeneSAFBchr19:5687679chr19:5664033ENST00000592224+1421599_915716917SAFB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HSD11B1L_SAFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSD11B1L_SAFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource