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Fusion gene ID: 1677 |
FusionGeneSummary for ANK3_ACTA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANK3_ACTA2 | Fusion gene ID: 1677 | Hgene | Tgene | Gene symbol | ANK3 | ACTA2 | Gene ID | 288 | 59 |
| Gene name | ankyrin 3 | actin, alpha 2, smooth muscle, aorta | |
| Synonyms | ANKYRIN-G|MRT37 | ACTSA | |
| Cytomap | 10q21.2 | 10q23.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin-3ankyrin 3, node of Ranvier (ankyrin G) | actin, aortic smooth musclealpha-cardiac actincell growth-inhibiting gene 46 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q12955 | P62736 | |
| Ensembl transtripts involved in fusion gene | ENST00000280772, ENST00000373827, ENST00000355288, ENST00000503366, ENST00000510382, ENST00000460468, | ENST00000224784, ENST00000458208, ENST00000480297, | |
| Fusion gene scores | * DoF score | 14 X 9 X 7=882 | 2 X 2 X 2=8 |
| # samples | 15 | 2 | |
| ** MAII score | log2(15/882*10)=-2.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANK3 [Title/Abstract] AND ACTA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-D5-6536-01A | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000280772 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000280772 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-intron | ENST00000280772 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| Frame-shift | ENST00000373827 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| Frame-shift | ENST00000373827 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| 5CDS-intron | ENST00000373827 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000355288 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000355288 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-intron | ENST00000355288 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000503366 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000503366 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-intron | ENST00000503366 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| 5UTR-3CDS | ENST00000510382 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| 5UTR-3CDS | ENST00000510382 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| 5UTR-intron | ENST00000510382 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000460468 | ENST00000224784 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-3CDS | ENST00000460468 | ENST00000458208 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
| intron-intron | ENST00000460468 | ENST00000480297 | ANK3 | chr10 | 62374944 | - | ACTA2 | chr10 | 90697999 | - |
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FusionProtFeatures for ANK3_ACTA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANK3 | ACTA2 |