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Fusion gene ID: 16749 |
FusionGeneSummary for HPRT1_HNRNPDL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HPRT1_HNRNPDL | Fusion gene ID: 16749 | Hgene | Tgene | Gene symbol | HPRT1 | HNRNPDL | Gene ID | 3251 | 9987 |
| Gene name | hypoxanthine phosphoribosyltransferase 1 | heterogeneous nuclear ribonucleoprotein D like | |
| Synonyms | HGPRT|HPRT | HNRNP|HNRPDL|JKTBP|JKTBP2|LGMD1G|laAUF1 | |
| Cytomap | Xq26.2-q26.3 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hypoxanthine-guanine phosphoribosyltransferaseHGPRTasehypoxanthine-guanine phosphoribosyltransferase 1testicular tissue protein Li 89 | heterogeneous nuclear ribonucleoprotein D-likeA+U-rich element RNA binding factorAU-rich element RNA-binding factorJKT41-binding proteinhnRNP D-likehnRNP DLprotein laAUF1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P00492 | O14979 | |
| Ensembl transtripts involved in fusion gene | ENST00000298556, ENST00000462974, | ENST00000295470, ENST00000349655, ENST00000602300, ENST00000502762, ENST00000514511, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 7 X 3=147 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/147*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HPRT1 [Title/Abstract] AND HNRNPDL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HPRT1 | GO:0006178 | guanine salvage | 19527031 |
| Hgene | HPRT1 | GO:0043103 | hypoxanthine salvage | 19527031 |
| Hgene | HPRT1 | GO:0046038 | GMP catabolic process | 19527031 |
| Hgene | HPRT1 | GO:0046040 | IMP metabolic process | 19527031 |
| Hgene | HPRT1 | GO:0051289 | protein homotetramerization | 9521733 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE467833 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000298556 | ENST00000295470 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| 3UTR-3CDS | ENST00000298556 | ENST00000349655 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| 3UTR-3CDS | ENST00000298556 | ENST00000602300 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| 3UTR-3CDS | ENST00000298556 | ENST00000502762 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| 3UTR-intron | ENST00000298556 | ENST00000514511 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| intron-3CDS | ENST00000462974 | ENST00000295470 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| intron-3CDS | ENST00000462974 | ENST00000349655 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| intron-3CDS | ENST00000462974 | ENST00000602300 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| intron-3CDS | ENST00000462974 | ENST00000502762 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
| intron-intron | ENST00000462974 | ENST00000514511 | HPRT1 | chrX | 133634339 | - | HNRNPDL | chr4 | 83349569 | - |
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FusionProtFeatures for HPRT1_HNRNPDL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HPRT1 | HNRNPDL |