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Fusion gene ID: 1674 |
FusionGeneSummary for ANK2_IGKC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANK2_IGKC | Fusion gene ID: 1674 | Hgene | Tgene | Gene symbol | ANK2 | IGKC | Gene ID | 287 | 3514 |
| Gene name | ankyrin 2 | immunoglobulin kappa constant | |
| Synonyms | ANK-2|LQT4|brank-2 | HCAK1|IGKCD|Km | |
| Cytomap | 4q25-q26 | 2p11.2 | |
| Type of gene | protein-coding | other | |
| Description | ankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrin | immunoglobulin kappa (invariant region)immunoglobulin kappa constant regionimmunoglobulin kappa light chain (VJ) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q01484 | P01834 | |
| Ensembl transtripts involved in fusion gene | ENST00000506722, ENST00000394537, ENST00000357077, ENST00000264366, ENST00000509550, ENST00000510275, ENST00000504887, | ENST00000390237, | |
| Fusion gene scores | * DoF score | 8 X 9 X 4=288 | 21 X 29 X 2=1218 |
| # samples | 11 | 35 | |
| ** MAII score | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/1218*10)=-1.799087306074 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANK2 [Title/Abstract] AND IGKC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA418420 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000506722 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000394537 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000357077 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000264366 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000509550 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000510275 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
| intron-3CDS | ENST00000504887 | ENST00000390237 | ANK2 | chr4 | 114135385 | + | IGKC | chr2 | 89156991 | + |
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FusionProtFeatures for ANK2_IGKC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANK2 | IGKC |