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Fusion gene ID: 16698 |
FusionGeneSummary for HOXB3_EPHA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HOXB3_EPHA5 | Fusion gene ID: 16698 | Hgene | Tgene | Gene symbol | HOXB3 | EPHA5 | Gene ID | 3213 | 2044 |
| Gene name | homeobox B3 | EPH receptor A5 | |
| Synonyms | HOX2|HOX2G|Hox-2.7 | CEK7|EHK-1|EHK1|EK7|HEK7|TYRO4 | |
| Cytomap | 17q21.32 | 4q13.1-q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2G | ephrin type-A receptor 5EPH homology kinase 1EPH-like kinase 7brain-specific kinasereceptor protein-tyrosine kinase HEK7tyrosine-protein kinase receptor EHK-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P14651 | P54756 | |
| Ensembl transtripts involved in fusion gene | ENST00000472863, ENST00000498678, ENST00000460160, ENST00000476342, ENST00000552000, ENST00000470495, ENST00000311626, ENST00000490677, ENST00000485909, ENST00000489475, ENST00000465120, | ENST00000273854, ENST00000432638, ENST00000354839, ENST00000511294, | |
| Fusion gene scores | * DoF score | 9 X 5 X 6=270 | 4 X 3 X 3=36 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HOXB3 [Title/Abstract] AND EPHA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HOXB3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9556594 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-ER-A2NE-06A | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000472863 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000472863 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000472863 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000472863 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000498678 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000498678 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000498678 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000498678 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000460160 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000460160 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000460160 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000460160 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000476342 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000476342 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000476342 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000476342 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| 5UTR-3CDS | ENST00000552000 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| 5UTR-3CDS | ENST00000552000 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| 5UTR-3CDS | ENST00000552000 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| 5UTR-3CDS | ENST00000552000 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000470495 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000470495 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000470495 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000470495 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000311626 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000311626 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000311626 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000311626 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000490677 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000490677 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000490677 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000490677 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000485909 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000485909 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000485909 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000485909 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000489475 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000489475 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000489475 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000489475 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000465120 | ENST00000273854 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000465120 | ENST00000432638 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000465120 | ENST00000354839 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
| intron-3CDS | ENST00000465120 | ENST00000511294 | HOXB3 | chr17 | 46681842 | - | EPHA5 | chr4 | 66509145 | - |
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FusionProtFeatures for HOXB3_EPHA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HOXB3 | EPHA5 |