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Fusion gene ID: 16660 |
FusionGeneSummary for HOMER1_MAST2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HOMER1_MAST2 | Fusion gene ID: 16660 | Hgene | Tgene | Gene symbol | HOMER1 | MAST2 | Gene ID | 9456 | 23139 |
| Gene name | homer scaffold protein 1 | microtubule associated serine/threonine kinase 2 | |
| Synonyms | HOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1 | MAST205|MTSSK | |
| Cytomap | 5q14.1 | 1p34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homer protein homolog 1homer homolog 1homer scaffolding protein 1homer, neuronal immediate early gene, 1homer-1 | microtubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86YM7 | Q6P0Q8 | |
| Ensembl transtripts involved in fusion gene | ENST00000334082, ENST00000535690, ENST00000508576, ENST00000282260, | ENST00000372009, ENST00000361297, ENST00000477968, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 8 X 8=576 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/576*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HOMER1 [Title/Abstract] AND MAST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HOMER1 | GO:0051592 | response to calcium ion | 14505576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7882-01A | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000334082 | ENST00000372009 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000334082 | ENST00000361297 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| 5CDS-intron | ENST00000334082 | ENST00000477968 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000535690 | ENST00000372009 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000535690 | ENST00000361297 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| 5CDS-intron | ENST00000535690 | ENST00000477968 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000508576 | ENST00000372009 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000508576 | ENST00000361297 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| 5CDS-intron | ENST00000508576 | ENST00000477968 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000282260 | ENST00000372009 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| In-frame | ENST00000282260 | ENST00000361297 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
| 5CDS-intron | ENST00000282260 | ENST00000477968 | HOMER1 | chr5 | 78808593 | - | MAST2 | chr1 | 46348036 | + |
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FusionProtFeatures for HOMER1_MAST2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HOMER1 | MAST2 |