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Fusion gene ID: 16649 |
FusionGeneSummary for HNRNPUL2_YY1AP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPUL2_YY1AP1 | Fusion gene ID: 16649 | Hgene | Tgene | Gene symbol | HNRNPUL2 | YY1AP1 | Gene ID | 221092 | 55249 |
| Gene name | heterogeneous nuclear ribonucleoprotein U like 2 | YY1 associated protein 1 | |
| Synonyms | HNRPUL2|SAF-A2 | GRNG|HCCA1|HCCA2|YY1AP | |
| Cytomap | 11q12.3 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein U-like protein 2scaffold-attachment factor A2 | YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q1KMD3 | Q9H869 | |
| Ensembl transtripts involved in fusion gene | ENST00000301785, | ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 5 X 1=25 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HNRNPUL2 [Title/Abstract] AND YY1AP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YY1AP1 | GO:0051726 | regulation of cell cycle | 17541814 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW249049 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - | ||
| ChiTaRS3.1 | AW247583 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000301785 | ENST00000311573 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000368340 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000347088 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000361831 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000355499 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000404643 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000407221 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-5UTR | ENST00000301785 | ENST00000359205 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000295566 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000368330 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000368339 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000535662 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000405763 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000438245 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
| intron-intron | ENST00000301785 | ENST00000476093 | HNRNPUL2 | chr11 | 62482596 | + | YY1AP1 | chr1 | 155658475 | - |
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FusionProtFeatures for HNRNPUL2_YY1AP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPUL2 | YY1AP1 |