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Fusion gene ID: 16643

FusionGeneSummary for HNRNPUL1_SLC8A2

Fusion gene summary

Fusion gene information	Fusion gene name: HNRNPUL1_SLC8A2
	Fusion gene ID: 16643
		Hgene	Tgene
	Gene symbol	HNRNPUL1	SLC8A2
	Gene ID	11100	6543
	Gene name	heterogeneous nuclear ribonucleoprotein U like 1	solute carrier family 8 member A2
	Synonyms	E1B-AP5\|E1BAP5\|HNRPUL1	NCX2
	Cytomap	19q13.2	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	heterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5	sodium/calcium exchanger 2Na(+)/Ca(2+)-exchange protein 2Na+/Ca2+-exchanging protein Nac2solute carrier family 8 (sodium/calcium exchanger), member 2solute carrier family 8 member 2
	Modification date	20180522	20180519
	UniProtAcc	Q9BUJ2	Q9UPR5
	Ensembl transtripts involved in fusion gene	ENST00000352456, ENST00000595018, ENST00000392006, ENST00000378215, ENST00000602130, ENST00000593587, ENST00000263367, ENST00000594207,	ENST00000236877, ENST00000539381, ENST00000542837, ENST00000601757,
Fusion gene scores	* DoF score	13 X 8 X 8=832	1 X 1 X 1=1
	# samples	13	1
	** MAII score	log2(13/832*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: HNRNPUL1 [Title/Abstract] AND SLC8A2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-EJ-5518-01A	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000352456	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000352456	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000352456	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000352456	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
In-frame	ENST00000595018	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000595018	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000595018	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000595018	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
In-frame	ENST00000392006	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000392006	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000392006	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000392006	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-3CDS	ENST00000378215	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-intron	ENST00000378215	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-5UTR	ENST00000378215	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-intron	ENST00000378215	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
In-frame	ENST00000602130	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000602130	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000602130	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000602130	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
In-frame	ENST00000593587	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000593587	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000593587	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000593587	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
In-frame	ENST00000263367	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000263367	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-5UTR	ENST00000263367	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
5CDS-intron	ENST00000263367	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-3CDS	ENST00000594207	ENST00000236877	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-intron	ENST00000594207	ENST00000539381	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-5UTR	ENST00000594207	ENST00000542837	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-
intron-intron	ENST00000594207	ENST00000601757	HNRNPUL1	chr19	41787180	+	SLC8A2	chr19	47960851	-

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FusionProtFeatures for HNRNPUL1_SLC8A2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNRNPUL1 Q9BUJ2	SLC8A2 Q9UPR5

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Fusion gene ID: 16643

FusionGeneSummary for HNRNPUL1_SLC8A2

FusionProtFeatures for HNRNPUL1_SLC8A2