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Fusion gene ID: 16593 |
FusionGeneSummary for HNRNPH3_HSD11B1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPH3_HSD11B1 | Fusion gene ID: 16593 | Hgene | Tgene | Gene symbol | HNRNPH3 | HSD11B1 | Gene ID | 3189 | 3290 |
| Gene name | heterogeneous nuclear ribonucleoprotein H3 | hydroxysteroid 11-beta dehydrogenase 1 | |
| Synonyms | 2H9|HNRPH3 | 11-DH|11-beta-HSD1|CORTRD2|HDL|HSD11|HSD11B|HSD11L|SDR26C1 | |
| Cytomap | 10q21.3 | 1q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein H3heterogeneous nuclear ribonucleoprotein 2H9hnRNP 2H9hnRNP H3 | corticosteroid 11-beta-dehydrogenase isozyme 1short chain dehydrogenase/reductase family 26C member 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P31942 | P28845 | |
| Ensembl transtripts involved in fusion gene | ENST00000469172, ENST00000265866, ENST00000441000, ENST00000354695, | ENST00000367028, ENST00000261465, ENST00000367027, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HNRNPH3 [Title/Abstract] AND HSD11B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG954179 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000469172 | ENST00000367028 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 3UTR-intron | ENST00000469172 | ENST00000261465 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 3UTR-intron | ENST00000469172 | ENST00000367027 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000265866 | ENST00000367028 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000265866 | ENST00000261465 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000265866 | ENST00000367027 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000441000 | ENST00000367028 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000441000 | ENST00000261465 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000441000 | ENST00000367027 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000354695 | ENST00000367028 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000354695 | ENST00000261465 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
| 5CDS-intron | ENST00000354695 | ENST00000367027 | HNRNPH3 | chr10 | 70099312 | + | HSD11B1 | chr1 | 209897701 | + |
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FusionProtFeatures for HNRNPH3_HSD11B1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPH3 | HSD11B1 |