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Fusion gene ID: 1659 |
FusionGeneSummary for ANAPC7_PAH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANAPC7_PAH | Fusion gene ID: 1659 | Hgene | Tgene | Gene symbol | ANAPC7 | PAH | Gene ID | 51434 | 5053 |
| Gene name | anaphase promoting complex subunit 7 | phenylalanine hydroxylase | |
| Synonyms | APC7 | PH|PKU|PKU1 | |
| Cytomap | 12q24.11 | 12q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anaphase-promoting complex subunit 7cyclosome subunit 7 | phenylalanine-4-hydroxylasephe-4-monooxygenasephenylalanine 4-monooxygenase | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9UJX3 | P00439 | |
| Ensembl transtripts involved in fusion gene | ENST00000455511, ENST00000481473, ENST00000450008, | ENST00000553106, ENST00000307000, ENST00000551988, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 4 X 4=80 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANAPC7 [Title/Abstract] AND PAH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANAPC7 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XQ-A8TA-01A | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000455511 | ENST00000553106 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| Frame-shift | ENST00000455511 | ENST00000307000 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| 5CDS-5UTR | ENST00000455511 | ENST00000551988 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| intron-3CDS | ENST00000481473 | ENST00000553106 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| intron-3CDS | ENST00000481473 | ENST00000307000 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| intron-5UTR | ENST00000481473 | ENST00000551988 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| Frame-shift | ENST00000450008 | ENST00000553106 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| Frame-shift | ENST00000450008 | ENST00000307000 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
| 5CDS-5UTR | ENST00000450008 | ENST00000551988 | ANAPC7 | chr12 | 110841332 | - | PAH | chr12 | 103271328 | - |
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FusionProtFeatures for ANAPC7_PAH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANAPC7 | PAH |