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Fusion gene ID: 16577 |
FusionGeneSummary for HNRNPH1_ACTN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPH1_ACTN1 | Fusion gene ID: 16577 | Hgene | Tgene | Gene symbol | HNRNPH1 | ACTN1 | Gene ID | 3187 | 87 |
| Gene name | heterogeneous nuclear ribonucleoprotein H1 | actinin alpha 1 | |
| Synonyms | HNRPH|HNRPH1|hnRNPH | BDPLT15 | |
| Cytomap | 5q35.3 | 14q24.1|14q22-q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein Hheterogeneous nuclear ribonucleoprotein H1 (H) | alpha-actinin-1F-actin cross-linking proteinactinin 1 smooth musclealpha-actinin cytoskeletal isoformnon-muscle alpha-actinin-1 | |
| Modification date | 20180524 | 20180522 | |
| UniProtAcc | P31943 | P12814 | |
| Ensembl transtripts involved in fusion gene | ENST00000393432, ENST00000442819, ENST00000356731, ENST00000329433, ENST00000510411, ENST00000511300, ENST00000524180, | ENST00000193403, ENST00000394419, ENST00000438964, ENST00000376839, ENST00000538545, ENST00000554508, | |
| Fusion gene scores | * DoF score | 11 X 13 X 4=572 | 9 X 10 X 3=270 |
| # samples | 12 | 11 | |
| ** MAII score | log2(12/572*10)=-2.25298074116987 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/270*10)=-1.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HNRNPH1 [Title/Abstract] AND ACTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HNRNPH1 | GO:0043484 | regulation of RNA splicing | 16946708 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CO249202 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000393432 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000393432 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000393432 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000393432 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000393432 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000393432 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000442819 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000356731 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000329433 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000510411 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000511300 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000193403 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000394419 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000438964 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000376839 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000538545 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
| intron-intron | ENST00000524180 | ENST00000554508 | HNRNPH1 | chr5 | 179049671 | - | ACTN1 | chr14 | 69363779 | - |
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FusionProtFeatures for HNRNPH1_ACTN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPH1 | ACTN1 |