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Fusion gene ID: 1656 |
FusionGeneSummary for ANAPC5_KDM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANAPC5_KDM2B | Fusion gene ID: 1656 | Hgene | Tgene | Gene symbol | ANAPC5 | KDM2B | Gene ID | 51433 | 84678 |
| Gene name | anaphase promoting complex subunit 5 | lysine demethylase 2B | |
| Synonyms | APC5 | CXXC2|FBXL10|Fbl10|JHDM1B|PCCX2 | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anaphase-promoting complex subunit 5cyclosome subunit 5 | lysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethy | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UJX4 | Q8NHM5 | |
| Ensembl transtripts involved in fusion gene | ENST00000441917, ENST00000541887, ENST00000261819, ENST00000535482, ENST00000544314, ENST00000344395, ENST00000536366, | ENST00000377069, ENST00000542973, ENST00000377071, ENST00000536437, ENST00000538046, ENST00000543852, | |
| Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 6 X 9 X 8=432 |
| # samples | 8 | 13 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANAPC5 [Title/Abstract] AND KDM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANAPC5 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
| Tgene | KDM2B | GO:0035518 | histone H2A monoubiquitination | 16943429 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A1LL-01A | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| TCGA | RV | STAD | TCGA-BR-8373-01A | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000441917 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000441917 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000441917 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000441917 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000441917 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000441917 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| Frame-shift | ENST00000541887 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000541887 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000541887 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000541887 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000541887 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000541887 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| Frame-shift | ENST00000261819 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000261819 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000261819 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000261819 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000261819 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000261819 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| Frame-shift | ENST00000535482 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000535482 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000535482 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000535482 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000535482 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000535482 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-3CDS | ENST00000544314 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-intron | ENST00000544314 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-intron | ENST00000544314 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-intron | ENST00000544314 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-intron | ENST00000544314 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5UTR-intron | ENST00000544314 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| Frame-shift | ENST00000344395 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000344395 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000344395 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000344395 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000344395 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| 5CDS-intron | ENST00000344395 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-3CDS | ENST00000536366 | ENST00000377069 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-intron | ENST00000536366 | ENST00000542973 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-intron | ENST00000536366 | ENST00000377071 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-intron | ENST00000536366 | ENST00000536437 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-intron | ENST00000536366 | ENST00000538046 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| intron-intron | ENST00000536366 | ENST00000543852 | ANAPC5 | chr12 | 121764899 | - | KDM2B | chr12 | 121958903 | - |
| In-frame | ENST00000441917 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000441917 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000441917 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000441917 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000441917 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000441917 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000541887 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000541887 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000541887 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000541887 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000541887 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000541887 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000261819 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000261819 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000261819 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000261819 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000261819 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000261819 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-3CDS | ENST00000535482 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-3CDS | ENST00000535482 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-3CDS | ENST00000535482 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-3CDS | ENST00000535482 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-intron | ENST00000535482 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| intron-intron | ENST00000535482 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-3CDS | ENST00000544314 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-3CDS | ENST00000544314 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-3CDS | ENST00000544314 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-3CDS | ENST00000544314 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-intron | ENST00000544314 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5UTR-intron | ENST00000544314 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000344395 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000344395 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000344395 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000344395 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000344395 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000344395 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000536366 | ENST00000377069 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000536366 | ENST00000542973 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| In-frame | ENST00000536366 | ENST00000377071 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| Frame-shift | ENST00000536366 | ENST00000536437 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000536366 | ENST00000538046 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
| 5CDS-intron | ENST00000536366 | ENST00000543852 | ANAPC5 | chr12 | 121773336 | - | KDM2B | chr12 | 121868272 | - |
Top |
FusionProtFeatures for ANAPC5_KDM2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANAPC5 | KDM2B |
| Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 209_249 | 316 | 756 | Repeat | Note=TPR 1 |
| Hgene | ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 250_300 | 316 | 756 | Repeat | Note=TPR 2 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 943_971 | 644 | 912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1014_1056 | 644 | 912 | Compositional bias | Note=Pro-rich |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1059_1105 | 644 | 912 | Domain | Note=F-box |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1222_1247 | 1207 | 1266 | Repeat | Note=LRR 4 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1248_1277 | 1207 | 1266 | Repeat | Note=LRR 5 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1278_1302 | 1207 | 1266 | Repeat | Note=LRR 6 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1303_1336 | 1207 | 1266 | Repeat | Note=LRR 7 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1278_1302 | 1276 | 1337 | Repeat | Note=LRR 6 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1303_1336 | 1276 | 1337 | Repeat | Note=LRR 7 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1093_1120 | 644 | 912 | Repeat | Note=LRR 1 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1133_1154 | 644 | 912 | Repeat | Note=LRR 2 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1156_1182 | 644 | 912 | Repeat | Note=LRR 3 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1222_1247 | 644 | 912 | Repeat | Note=LRR 4 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1248_1277 | 644 | 912 | Repeat | Note=LRR 5 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1278_1302 | 644 | 912 | Repeat | Note=LRR 6 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 1303_1336 | 644 | 912 | Repeat | Note=LRR 7 |
| Tgene | >KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 659_725 | 644 | 912 | Zinc finger | PHD-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 301_337 | 316 | 756 | Repeat | Note=TPR 3 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 338_378 | 316 | 756 | Repeat | Note=TPR 4 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 379_418 | 316 | 756 | Repeat | Note=TPR 5 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 419_466 | 316 | 756 | Repeat | Note=TPR 6 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 467_500 | 316 | 756 | Repeat | Note=TPR 7 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 501_540 | 316 | 756 | Repeat | Note=TPR 8 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 541_580 | 316 | 756 | Repeat | Note=TPR 9 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 581_620 | 316 | 756 | Repeat | Note=TPR 10 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 621_660 | 316 | 756 | Repeat | Note=TPR 11 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 661_696 | 316 | 756 | Repeat | Note=TPR 12 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000261819 | - | 7 | 17 | 697_736 | 316 | 756 | Repeat | Note=TPR 13 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 209_249 | 217 | 644 | Repeat | Note=TPR 1 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 250_300 | 217 | 644 | Repeat | Note=TPR 2 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 301_337 | 217 | 644 | Repeat | Note=TPR 3 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 338_378 | 217 | 644 | Repeat | Note=TPR 4 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 379_418 | 217 | 644 | Repeat | Note=TPR 5 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 419_466 | 217 | 644 | Repeat | Note=TPR 6 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 467_500 | 217 | 644 | Repeat | Note=TPR 7 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 501_540 | 217 | 644 | Repeat | Note=TPR 8 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 541_580 | 217 | 644 | Repeat | Note=TPR 9 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 581_620 | 217 | 644 | Repeat | Note=TPR 10 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 621_660 | 217 | 644 | Repeat | Note=TPR 11 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 661_696 | 217 | 644 | Repeat | Note=TPR 12 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000344395 | - | 5 | 15 | 697_736 | 217 | 644 | Repeat | Note=TPR 13 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 209_249 | 217 | 644 | Repeat | Note=TPR 1 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 250_300 | 217 | 644 | Repeat | Note=TPR 2 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 301_337 | 217 | 644 | Repeat | Note=TPR 3 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 338_378 | 217 | 644 | Repeat | Note=TPR 4 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 379_418 | 217 | 644 | Repeat | Note=TPR 5 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 419_466 | 217 | 644 | Repeat | Note=TPR 6 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 467_500 | 217 | 644 | Repeat | Note=TPR 7 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 501_540 | 217 | 644 | Repeat | Note=TPR 8 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 541_580 | 217 | 644 | Repeat | Note=TPR 9 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 581_620 | 217 | 644 | Repeat | Note=TPR 10 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 621_660 | 217 | 644 | Repeat | Note=TPR 11 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 661_696 | 217 | 644 | Repeat | Note=TPR 12 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000441917 | - | 6 | 16 | 697_736 | 217 | 644 | Repeat | Note=TPR 13 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 209_249 | 195 | 220 | Repeat | Note=TPR 1 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 250_300 | 195 | 220 | Repeat | Note=TPR 2 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 301_337 | 195 | 220 | Repeat | Note=TPR 3 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 338_378 | 195 | 220 | Repeat | Note=TPR 4 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 379_418 | 195 | 220 | Repeat | Note=TPR 5 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 419_466 | 195 | 220 | Repeat | Note=TPR 6 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 467_500 | 195 | 220 | Repeat | Note=TPR 7 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 501_540 | 195 | 220 | Repeat | Note=TPR 8 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 541_580 | 195 | 220 | Repeat | Note=TPR 9 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 581_620 | 195 | 220 | Repeat | Note=TPR 10 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 621_660 | 195 | 220 | Repeat | Note=TPR 11 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 661_696 | 195 | 220 | Repeat | Note=TPR 12 |
| Hgene | >ANAPC5 | chr12:121773336 | chr12:121868272 | ENST00000536366 | - | 4 | 5 | 697_736 | 195 | 220 | Repeat | Note=TPR 13 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 943_971 | 1207 | 1266 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 943_971 | 1276 | 1337 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1014_1056 | 1207 | 1266 | Compositional bias | Note=Pro-rich |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 409_430 | 1207 | 1266 | Compositional bias | Note=Glu-rich |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1014_1056 | 1276 | 1337 | Compositional bias | Note=Pro-rich |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 409_430 | 1276 | 1337 | Compositional bias | Note=Glu-rich |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 409_430 | 644 | 912 | Compositional bias | Note=Glu-rich |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1059_1105 | 1207 | 1266 | Domain | Note=F-box |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 178_346 | 1207 | 1266 | Domain | JmjC |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1059_1105 | 1276 | 1337 | Domain | Note=F-box |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 178_346 | 1276 | 1337 | Domain | JmjC |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 178_346 | 644 | 912 | Domain | JmjC |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1093_1120 | 1207 | 1266 | Repeat | Note=LRR 1 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1133_1154 | 1207 | 1266 | Repeat | Note=LRR 2 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 1156_1182 | 1207 | 1266 | Repeat | Note=LRR 3 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1093_1120 | 1276 | 1337 | Repeat | Note=LRR 1 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1133_1154 | 1276 | 1337 | Repeat | Note=LRR 2 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1156_1182 | 1276 | 1337 | Repeat | Note=LRR 3 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1222_1247 | 1276 | 1337 | Repeat | Note=LRR 4 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 1248_1277 | 1276 | 1337 | Repeat | Note=LRR 5 |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 606_652 | 1207 | 1266 | Zinc finger | CXXC-type |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377069 | - | 20 | 23 | 659_725 | 1207 | 1266 | Zinc finger | PHD-type |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 606_652 | 1276 | 1337 | Zinc finger | CXXC-type |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000377071 | - | 21 | 23 | 659_725 | 1276 | 1337 | Zinc finger | PHD-type |
| Tgene | KDM2B | chr12:121773336 | chr12:121868272 | ENST00000542973 | - | 11 | 14 | 606_652 | 644 | 912 | Zinc finger | CXXC-type |
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FusionGeneSequence for ANAPC5_KDM2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANAPC5_KDM2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANAPC5 | PABPC1, CDC27, ZBTB16, ANAPC1, CDT1, EP300, CREBBP, MDC1, MAPK6, SMARCAD1, E2F1, SH3KBP1, USP37, CUL4A, FBXO5, ANAPC4, ANAPC2, ANAPC7, CDC23, CDC16, ANAPC13, PAXIP1, TP53BP1, NOTCH1, ANAPC15, TRIM33, CDC20, PTEN, SOX2, BACH1, PHF8, LATS2, HECW2, UBE2S, TFDP1, FZR1, PENK, GRAP2, MAGIX, KNG1, TTLL1, PIFO, ANAPC16, GTF2E1, OFD1, XPO1, CFAP97, C16orf87, GPR156, CRYL1, L3MBTL1, ANO6, KIAA1683, C6orf141, NCAPH2, SNX21 | KDM2B | BCOR, PCGF1, SKP1, EZH2, CEBPE, LZTR1, JUN, CUL1, SIN3A, PCGF3, RNF2, RYBP, YAF2, HIST1H3A, KIAA0368, KDM2B, UBE2D1, ACBD3, RBX1, FOS, NANOG, POU5F1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANAPC5_KDM2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANAPC5_KDM2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KDM2B | C0036341 | Schizophrenia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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