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Fusion gene ID: 16544 |
FusionGeneSummary for HNRNPA3_PTPN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPA3_PTPN1 | Fusion gene ID: 16544 | Hgene | Tgene | Gene symbol | HNRNPA3 | PTPN1 | Gene ID | 220988 | 5770 |
| Gene name | heterogeneous nuclear ribonucleoprotein A3 | protein tyrosine phosphatase, non-receptor type 1 | |
| Synonyms | 2610510D13Rik|D10S102|FBRNP|HNRPA3 | PTP1B | |
| Cytomap | 2q31.2 | 20q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein A3 | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P51991 | P18031 | |
| Ensembl transtripts involved in fusion gene | ENST00000392524, ENST00000411529, ENST00000435711, | ENST00000371621, ENST00000541713, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 5 X 5=175 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/4*10)=2.90689059560852 | log2(10/175*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HNRNPA3 [Title/Abstract] AND PTPN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
| Tgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
| Tgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
| Tgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
| Tgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF877638 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + | ||
| ChiTaRS3.1 | BF877639 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000392524 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| intron-intron | ENST00000392524 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| 3UTR-intron | ENST00000411529 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| 3UTR-intron | ENST00000411529 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| intron-intron | ENST00000435711 | ENST00000371621 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
| intron-intron | ENST00000435711 | ENST00000541713 | HNRNPA3 | chr2 | 178088060 | - | PTPN1 | chr20 | 49192473 | + |
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FusionProtFeatures for HNRNPA3_PTPN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPA3 | PTPN1 |