|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16520 |
FusionGeneSummary for HNRNPA1_BEST3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNRNPA1_BEST3 | Fusion gene ID: 16520 | Hgene | Tgene | Gene symbol | HNRNPA1 | BEST3 | Gene ID | 3178 | 144453 |
| Gene name | heterogeneous nuclear ribonucleoprotein A1 | bestrophin 3 | |
| Synonyms | ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1 | VMD2L3 | |
| Cytomap | 12q13.13 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-lik | bestrophin-3vitelliform macular dystrophy 2-like 3vitelliform macular dystrophy 2-like protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P09651 | Q8N1M1 | |
| Ensembl transtripts involved in fusion gene | ENST00000546500, ENST00000340913, ENST00000330752, ENST00000547276, ENST00000551803, | ENST00000331471, ENST00000488961, ENST00000330891, ENST00000553096, ENST00000476098, ENST00000266661, ENST00000551160, ENST00000393365, ENST00000533674, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 6 X 5=300 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(10/300*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HNRNPA1 [Title/Abstract] AND BEST3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HNRNPA1 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 23935072 |
| Hgene | HNRNPA1 | GO:0051168 | nuclear export | 8521471 |
| Hgene | HNRNPA1 | GO:0051170 | import into nucleus | 8521471 |
| Hgene | HNRNPA1 | GO:1903936 | cellular response to sodium arsenite | 27694260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CR748314 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000546500 | ENST00000331471 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000488961 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000330891 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000553096 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000476098 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000266661 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000551160 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000393365 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000546500 | ENST00000533674 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000331471 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000488961 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000330891 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000553096 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000476098 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000266661 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000551160 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000393365 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000340913 | ENST00000533674 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000331471 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000488961 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000330891 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000553096 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000476098 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000266661 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000551160 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000393365 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000330752 | ENST00000533674 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000331471 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000488961 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000330891 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000553096 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000476098 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000266661 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000551160 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000393365 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000547276 | ENST00000533674 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000331471 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000488961 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000330891 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000553096 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000476098 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000266661 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000551160 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000393365 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
| intron-intron | ENST00000551803 | ENST00000533674 | HNRNPA1 | chr12 | 54674858 | + | BEST3 | chr12 | 70065944 | - |
Top |
FusionProtFeatures for HNRNPA1_BEST3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNRNPA1 | BEST3 |