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Fusion gene ID: 1650

FusionGeneSummary for ANAPC4_RBPJ

Fusion gene summary

Fusion gene information	Fusion gene name: ANAPC4_RBPJ
	Fusion gene ID: 1650
		Hgene	Tgene
	Gene symbol	ANAPC4	RBPJ
	Gene ID	29945	3516
	Gene name	anaphase promoting complex subunit 4	recombination signal binding protein for immunoglobulin kappa J region
	Synonyms	APC4	AOS3\|CBF1\|IGKJRB\|IGKJRB1\|KBF2\|RBP-J\|RBPJK\|RBPSUH\|SUH\|csl
	Cytomap	4p15.2	4p15.2
	Type of gene	protein-coding	protein-coding
	Description	anaphase-promoting complex subunit 4cyclosome subunit 4	recombining binding protein suppressor of hairlessCBF-1H-2K binding factor-2RBP-J kappaRBP-JKimmunoglobulin kappa J region recombination signal binding protein 1renal carcinoma antigen NY-REN-30suppressor of hairless homolog
	Modification date	20180523	20180525
	UniProtAcc	Q9UJX5	Q06330
	Ensembl transtripts involved in fusion gene	ENST00000315368, ENST00000510092,	ENST00000345843, ENST00000342295, ENST00000361572, ENST00000348160, ENST00000355476, ENST00000511401, ENST00000507561, ENST00000504907, ENST00000342320,
Fusion gene scores	* DoF score	2 X 2 X 2=8	7 X 7 X 4=196
	# samples	2	7
	** MAII score	log2(2/8*10)=1.32192809488736	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANAPC4 [Title/Abstract] AND RBPJ [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Transcription factor involved fusion gene, inframe and retained DNA-binding domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANAPC4	GO:0070979	protein K11-linked ubiquitination	18485873
Tgene	RBPJ	GO:0007221	positive regulation of transcription of Notch receptor target	21102556
Tgene	RBPJ	GO:0045892	negative regulation of transcription, DNA-templated	10713164
Tgene	RBPJ	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	23303788

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PRAD	TCGA-XK-AAJA-01A	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000315368	ENST00000345843	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000315368	ENST00000342295	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000315368	ENST00000361572	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000315368	ENST00000348160	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000315368	ENST00000355476	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-3UTR	ENST00000315368	ENST00000511401	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000315368	ENST00000507561	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000315368	ENST00000504907	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000315368	ENST00000342320	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000510092	ENST00000345843	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000510092	ENST00000342295	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000510092	ENST00000361572	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000510092	ENST00000348160	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
In-frame	ENST00000510092	ENST00000355476	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-3UTR	ENST00000510092	ENST00000511401	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000510092	ENST00000507561	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000510092	ENST00000504907	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+
5CDS-5UTR	ENST00000510092	ENST00000342320	ANAPC4	chr4	25398521	+	RBPJ	chr4	26407797	+

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FusionProtFeatures for ANAPC4_RBPJ

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANAPC4 Q9UJX5	RBPJ Q06330

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Fusion gene ID: 1650

FusionGeneSummary for ANAPC4_RBPJ

FusionProtFeatures for ANAPC4_RBPJ