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Fusion gene ID: 16484 |
FusionGeneSummary for HMGN3_NCOA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGN3_NCOA2 | Fusion gene ID: 16484 | Hgene | Tgene | Gene symbol | HMGN3 | NCOA2 | Gene ID | 9324 | 10499 |
| Gene name | high mobility group nucleosomal binding domain 3 | nuclear receptor coactivator 2 | |
| Synonyms | PNAS-24|PNAS-25|TRIP7 | GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 | |
| Cytomap | 6q14.1 | 8q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | high mobility group nucleosome-binding domain-containing protein 3TR-interacting protein 7thyroid hormone receptor interacting protein 7 | nuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q15651 | Q15596 | |
| Ensembl transtripts involved in fusion gene | ENST00000275036, ENST00000344726, | ENST00000452400, ENST00000267974, ENST00000524223, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 6 X 7 X 2=84 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HMGN3 [Title/Abstract] AND NCOA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG222207 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000275036 | ENST00000452400 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000275036 | ENST00000267974 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000275036 | ENST00000524223 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000452400 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000267974 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000524223 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
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FusionProtFeatures for HMGN3_NCOA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGN3 | NCOA2 |