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Fusion gene ID: 1647 |
FusionGeneSummary for ANAPC2_CEBPA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANAPC2_CEBPA | Fusion gene ID: 1647 | Hgene | Tgene | Gene symbol | ANAPC2 | CEBPA | Gene ID | 29882 | 1050 |
| Gene name | anaphase promoting complex subunit 2 | CCAAT enhancer binding protein alpha | |
| Synonyms | APC2 | C/EBP-alpha|CEBP | |
| Cytomap | 9q34.3 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anaphase-promoting complex subunit 2cyclosome subunit 2 | CCAAT/enhancer-binding protein alphaCCAAT/enhancer binding protein (C/EBP), alpha | |
| Modification date | 20180523 | 20180521 | |
| UniProtAcc | Q9UJX6 | P49715 | |
| Ensembl transtripts involved in fusion gene | ENST00000487917, ENST00000323927, | ENST00000498907, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANAPC2 [Title/Abstract] AND CEBPA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANAPC2 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
| Tgene | CEBPA | GO:0006351 | transcription, DNA-templated | 15664994 |
| Tgene | CEBPA | GO:0008285 | negative regulation of cell proliferation | 14660596 |
| Tgene | CEBPA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7959007|20972335 |
| Tgene | CEBPA | GO:0045945 | positive regulation of transcription by RNA polymerase III | 12695546 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LAML | TCGA-AB-2880-03A | ANAPC2 | chr9 | 140074958 | - | CEBPA | chr19 | 33792417 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000487917 | ENST00000498907 | ANAPC2 | chr9 | 140074958 | - | CEBPA | chr19 | 33792417 | - |
| intron-3CDS | ENST00000323927 | ENST00000498907 | ANAPC2 | chr9 | 140074958 | - | CEBPA | chr19 | 33792417 | - |
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FusionProtFeatures for ANAPC2_CEBPA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANAPC2 | CEBPA |