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Fusion gene ID: 16462 |
FusionGeneSummary for HMGB2_PTMA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGB2_PTMA | Fusion gene ID: 16462 | Hgene | Tgene | Gene symbol | HMGB2 | PTMA | Gene ID | 3148 | 5757 |
| Gene name | high mobility group box 2 | prothymosin alpha | |
| Synonyms | HMG2 | TMSA | |
| Cytomap | 4q34.1 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | high mobility group protein B2HMG-2high mobility group protein 2high-mobility group (nonhistone chromosomal) protein 2 | prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/- | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P26583 | P06454 | |
| Ensembl transtripts involved in fusion gene | ENST00000296503, ENST00000438704, ENST00000446922, | ENST00000466801, ENST00000409321, ENST00000409115, ENST00000341369, ENST00000409683, ENST00000410064, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 17 X 17 X 2=578 |
| # samples | 4 | 18 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/578*10)=-1.683072586171 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HMGB2 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HMGB2 | GO:0001938 | positive regulation of endothelial cell proliferation | 19811285 |
| Hgene | HMGB2 | GO:0006357 | regulation of transcription by RNA polymerase II | 7797075 |
| Hgene | HMGB2 | GO:0032075 | positive regulation of nuclease activity | 978439 |
| Hgene | HMGB2 | GO:0043388 | positive regulation of DNA binding | 19965638 |
| Hgene | HMGB2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9636147 |
| Hgene | HMGB2 | GO:0045893 | positive regulation of transcription, DNA-templated | 19965638 |
| Hgene | HMGB2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19223331|19965638 |
| Hgene | HMGB2 | GO:0050829 | defense response to Gram-negative bacterium | 23877675 |
| Hgene | HMGB2 | GO:0050830 | defense response to Gram-positive bacterium | 23877675 |
| Hgene | HMGB2 | GO:0060326 | cell chemotaxis | 19811285 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM836871 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000296503 | ENST00000466801 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000296503 | ENST00000409321 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000296503 | ENST00000409115 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000296503 | ENST00000341369 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000296503 | ENST00000409683 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000296503 | ENST00000410064 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000466801 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000409321 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000409115 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000341369 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000409683 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000438704 | ENST00000410064 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000466801 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000409321 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000409115 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000341369 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000409683 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
| intron-3UTR | ENST00000446922 | ENST00000410064 | HMGB2 | chr4 | 174254250 | - | PTMA | chr2 | 232576643 | + |
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FusionProtFeatures for HMGB2_PTMA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGB2 | PTMA |