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Fusion gene ID: 16459 |
FusionGeneSummary for HMGB2_CAMK1D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGB2_CAMK1D | Fusion gene ID: 16459 | Hgene | Tgene | Gene symbol | HMGB2 | CAMK1D | Gene ID | 3148 | 57118 |
| Gene name | high mobility group box 2 | calcium/calmodulin dependent protein kinase ID | |
| Synonyms | HMG2 | CKLiK|CaM-K1|CaMKID | |
| Cytomap | 4q34.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | high mobility group protein B2HMG-2high mobility group protein 2high-mobility group (nonhistone chromosomal) protein 2 | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P26583 | Q8IU85 | |
| Ensembl transtripts involved in fusion gene | ENST00000296503, ENST00000438704, ENST00000446922, | ENST00000378847, ENST00000487696, ENST00000378845, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 8 X 9 X 6=432 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HMGB2 [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HMGB2 | GO:0001938 | positive regulation of endothelial cell proliferation | 19811285 |
| Hgene | HMGB2 | GO:0006357 | regulation of transcription by RNA polymerase II | 7797075 |
| Hgene | HMGB2 | GO:0032075 | positive regulation of nuclease activity | 978439 |
| Hgene | HMGB2 | GO:0043388 | positive regulation of DNA binding | 19965638 |
| Hgene | HMGB2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9636147 |
| Hgene | HMGB2 | GO:0045893 | positive regulation of transcription, DNA-templated | 19965638 |
| Hgene | HMGB2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19223331|19965638 |
| Hgene | HMGB2 | GO:0050829 | defense response to Gram-negative bacterium | 23877675 |
| Hgene | HMGB2 | GO:0050830 | defense response to Gram-positive bacterium | 23877675 |
| Hgene | HMGB2 | GO:0060326 | cell chemotaxis | 19811285 |
| Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF062889 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000296503 | ENST00000378847 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000296503 | ENST00000487696 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000296503 | ENST00000378845 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000438704 | ENST00000378847 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000438704 | ENST00000487696 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000438704 | ENST00000378845 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000446922 | ENST00000378847 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000446922 | ENST00000487696 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
| intron-intron | ENST00000446922 | ENST00000378845 | HMGB2 | chr4 | 174253195 | + | CAMK1D | chr10 | 12834956 | - |
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FusionProtFeatures for HMGB2_CAMK1D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGB2 | CAMK1D |