|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16411 |
FusionGeneSummary for HMBOX1_FSTL5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMBOX1_FSTL5 | Fusion gene ID: 16411 | Hgene | Tgene | Gene symbol | HMBOX1 | FSTL5 | Gene ID | 79618 | 56884 |
| Gene name | homeobox containing 1 | follistatin like 5 | |
| Synonyms | HNF1LA|HOT1|PBHNF | - | |
| Cytomap | 8p21.1-p12 | 4q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox-containing protein 1homeobox telomere-binding protein 1homeobox-containing protein PBHNF | follistatin-related protein 5follistatin-like protein 5 | |
| Modification date | 20180520 | 20180519 | |
| UniProtAcc | Q6NT76 | Q8N475 | |
| Ensembl transtripts involved in fusion gene | ENST00000403668, ENST00000444075, ENST00000287701, ENST00000558662, ENST00000523613, ENST00000397358, ENST00000519047, ENST00000355231, ENST00000524238, ENST00000517386, | ENST00000306100, ENST00000379164, ENST00000536695, ENST00000427802, ENST00000511170, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 2 X 1 X 1=2 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: HMBOX1 [Title/Abstract] AND FSTL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HMBOX1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21839858 |
| Hgene | HMBOX1 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 23685356 |
| Hgene | HMBOX1 | GO:0045892 | negative regulation of transcription, DNA-templated | 19757162 |
| Hgene | HMBOX1 | GO:0051973 | positive regulation of telomerase activity | 23685356 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2O-01A | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000403668 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000403668 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000403668 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000403668 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000403668 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000444075 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000444075 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000444075 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000444075 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000444075 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000287701 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000287701 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000287701 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000287701 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000287701 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000558662 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000558662 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000558662 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000558662 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000558662 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000523613 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000523613 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000523613 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000523613 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000523613 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000397358 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000397358 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000397358 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000397358 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000397358 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000519047 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000519047 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000519047 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000519047 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000519047 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000355231 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000355231 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000355231 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000355231 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000355231 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000524238 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000524238 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000524238 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| Frame-shift | ENST00000524238 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| 5CDS-5UTR | ENST00000524238 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| intron-3CDS | ENST00000517386 | ENST00000306100 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| intron-3CDS | ENST00000517386 | ENST00000379164 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| intron-3CDS | ENST00000517386 | ENST00000536695 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| intron-3CDS | ENST00000517386 | ENST00000427802 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
| intron-5UTR | ENST00000517386 | ENST00000511170 | HMBOX1 | chr8 | 28837673 | + | FSTL5 | chr4 | 162508727 | - |
Top |
FusionProtFeatures for HMBOX1_FSTL5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMBOX1 | FSTL5 |