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Fusion gene ID: 16380 |
FusionGeneSummary for HLA-DRB5_DTX3L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HLA-DRB5_DTX3L | Fusion gene ID: 16380 | Hgene | Tgene | Gene symbol | HLA-DRB5 | DTX3L | Gene ID | 3127 | 151636 |
| Gene name | major histocompatibility complex, class II, DR beta 5 | deltex E3 ubiquitin ligase 3L | |
| Synonyms | - | BBAP|RNF143 | |
| Cytomap | 6p21.32 | 3q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | major histocompatibility complex, class II, DR beta 5DR beta-5HLA class II histocompatibility antigen, DR-5 beta chainMHC class II antigen DRB5 | E3 ubiquitin-protein ligase DTX3LB-lymphoma- and BAL-associated proteinRING-type E3 ubiquitin transferase DTX3Ldeltex 3 like, E3 ubiquitin ligasedeltex 3-likerhysin-2rhysin2 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q30154 | Q8TDB6 | |
| Ensembl transtripts involved in fusion gene | ENST00000374975, | ENST00000296161, ENST00000383661, | |
| Fusion gene scores | * DoF score | 3 X 4 X 1=12 | 4 X 5 X 1=20 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HLA-DRB5 [Title/Abstract] AND DTX3L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DTX3L | GO:0010390 | histone monoubiquitination | 19818714|28525742 |
| Tgene | DTX3L | GO:0070936 | protein K48-linked ubiquitination | 26479788 |
| Tgene | DTX3L | GO:1901666 | positive regulation of NAD+ ADP-ribosyltransferase activity | 28525742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB343360 | HLA-DRB5 | chr6 | 32485331 | + | DTX3L | chr3 | 122293268 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000374975 | ENST00000296161 | HLA-DRB5 | chr6 | 32485331 | + | DTX3L | chr3 | 122293268 | - |
| intron-intron | ENST00000374975 | ENST00000383661 | HLA-DRB5 | chr6 | 32485331 | + | DTX3L | chr3 | 122293268 | - |
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FusionProtFeatures for HLA-DRB5_DTX3L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HLA-DRB5 | DTX3L |