|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16305 |
FusionGeneSummary for HK1_GNL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HK1_GNL1 | Fusion gene ID: 16305 | Hgene | Tgene | Gene symbol | HK1 | GNL1 | Gene ID | 255061 | 2794 |
| Gene name | tachykinin 4 | G protein nucleolar 1 (putative) | |
| Synonyms | EK|HK-1|HK1|PPT-C | HSR1 | |
| Cytomap | 17q21.33 | 6p21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin) | guanine nucleotide-binding protein-like 1GTP-binding protein HSR1HSR1 GTP-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P19367 | P36915 | |
| Ensembl transtripts involved in fusion gene | ENST00000360289, ENST00000448642, ENST00000404387, ENST00000298649, ENST00000359426, ENST00000494253, | ENST00000376621, ENST00000383450, ENST00000441604, ENST00000550904, ENST00000428189, ENST00000551708, ENST00000437917, ENST00000548423, ENST00000383596, ENST00000550942, ENST00000454829, ENST00000552589, ENST00000417834, ENST00000551903, | |
| Fusion gene scores | * DoF score | 7 X 10 X 3=210 | 3 X 4 X 1=12 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HK1 [Title/Abstract] AND GNL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HK1 | GO:1902093 | positive regulation of flagellated sperm motility | 17437961 |
| Tgene | GNL1 | GO:0006974 | cellular response to DNA damage stimulus | 17525332 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC048213 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000360289 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000360289 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000448642 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000404387 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000298649 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| 5CDS-intron | ENST00000359426 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000376621 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000383450 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000441604 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000550904 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000428189 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000551708 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000437917 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000548423 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000383596 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000550942 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000454829 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000552589 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000417834 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
| intron-intron | ENST00000494253 | ENST00000551903 | HK1 | chr10 | 71160769 | - | GNL1 | chr6 | 1854676 | - |
Top |
FusionProtFeatures for HK1_GNL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HK1 | GNL1 |