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Fusion gene ID: 1625

FusionGeneSummary for AMOTL2_ADD3

Fusion gene summary

Fusion gene information	Fusion gene name: AMOTL2_ADD3
	Fusion gene ID: 1625
		Hgene	Tgene
	Gene symbol	AMOTL2	ADD3
	Gene ID	51421	120
	Gene name	angiomotin like 2	adducin 3
	Synonyms	LCCP	ADDL\|CPSQ3
	Cytomap	3q22.2	10q25.1-q25.2
	Type of gene	protein-coding	protein-coding
	Description	angiomotin-like protein 2Leman coiled-coil protein	gamma-adducinadducin 3 (gamma)adducin-like protein 70
	Modification date	20180523	20180523
	UniProtAcc	Q9Y2J4	Q9UEY8
	Ensembl transtripts involved in fusion gene	ENST00000249883, ENST00000422605, ENST00000514516, ENST00000513145, ENST00000511759,	ENST00000360162, ENST00000356080, ENST00000277900, ENST00000497125,
Fusion gene scores	* DoF score	3 X 3 X 1=9	5 X 5 X 2=50
	# samples	3	5
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/50*10)=0
Context	PubMed: AMOTL2 [Title/Abstract] AND ADD3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			C16484	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000249883	ENST00000360162	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000249883	ENST00000356080	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000249883	ENST00000277900	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-intron	ENST00000249883	ENST00000497125	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000422605	ENST00000360162	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000422605	ENST00000356080	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000422605	ENST00000277900	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-intron	ENST00000422605	ENST00000497125	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000514516	ENST00000360162	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000514516	ENST00000356080	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000514516	ENST00000277900	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-intron	ENST00000514516	ENST00000497125	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000513145	ENST00000360162	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000513145	ENST00000356080	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000513145	ENST00000277900	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-intron	ENST00000513145	ENST00000497125	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000511759	ENST00000360162	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000511759	ENST00000356080	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-3UTR	ENST00000511759	ENST00000277900	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+
intron-intron	ENST00000511759	ENST00000497125	AMOTL2	chr3	134075089	+	ADD3	chr10	111893426	+

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FusionProtFeatures for AMOTL2_ADD3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AMOTL2 Q9Y2J4	ADD3 Q9UEY8

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Fusion gene ID: 1625

FusionGeneSummary for AMOTL2_ADD3

FusionProtFeatures for AMOTL2_ADD3