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Fusion gene ID: 16206 |
FusionGeneSummary for HIPK2_MYCBP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HIPK2_MYCBP2 | Fusion gene ID: 16206 | Hgene | Tgene | Gene symbol | HIPK2 | MYCBP2 | Gene ID | 28996 | 23077 |
| Gene name | homeodomain interacting protein kinase 2 | MYC binding protein 2, E3 ubiquitin protein ligase | |
| Synonyms | PRO0593 | Myc-bp2|PAM|Phr | |
| Cytomap | 7q34 | 13q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeodomain-interacting protein kinase 2hHIPk2 | E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9H2X6 | O75592 | |
| Ensembl transtripts involved in fusion gene | ENST00000406875, ENST00000428878, ENST00000342645, | ENST00000544440, ENST00000407578, ENST00000357337, ENST00000360084, ENST00000482517, | |
| Fusion gene scores | * DoF score | 11 X 7 X 9=693 | 2 X 4 X 2=16 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/693*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/16*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HIPK2 [Title/Abstract] AND MYCBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HIPK2 | GO:0006468 | protein phosphorylation | 19448668 |
| Hgene | HIPK2 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 14647468 |
| Hgene | HIPK2 | GO:0045766 | positive regulation of angiogenesis | 19046997 |
| Hgene | HIPK2 | GO:0060395 | SMAD protein signal transduction | 12874272 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VN-A88L-01A | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| TCGA | LD | PRAD | TCGA-VN-A88L-01A | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000406875 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000406875 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000406875 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-5UTR | ENST00000406875 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-intron | ENST00000406875 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000428878 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000428878 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000428878 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-5UTR | ENST00000428878 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-intron | ENST00000428878 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000342645 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000342645 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000342645 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-5UTR | ENST00000342645 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| 5CDS-intron | ENST00000342645 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77739526 | - |
| Frame-shift | ENST00000406875 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000406875 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000406875 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-5UTR | ENST00000406875 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-intron | ENST00000406875 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000428878 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000428878 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000428878 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-5UTR | ENST00000428878 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-intron | ENST00000428878 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000342645 | ENST00000544440 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000342645 | ENST00000407578 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| Frame-shift | ENST00000342645 | ENST00000357337 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-5UTR | ENST00000342645 | ENST00000360084 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
| 5CDS-intron | ENST00000342645 | ENST00000482517 | HIPK2 | chr7 | 139415731 | - | MYCBP2 | chr13 | 77732244 | - |
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FusionProtFeatures for HIPK2_MYCBP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HIPK2 | MYCBP2 |