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Fusion gene ID: 16168 |
FusionGeneSummary for HID1_DNAH17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HID1_DNAH17 | Fusion gene ID: 16168 | Hgene | Tgene | Gene symbol | HID1 | DNAH17 | Gene ID | 283987 | 8632 |
| Gene name | HID1 domain containing | dynein axonemal heavy chain 17 | |
| Synonyms | 17orf28|C17orf28|DMC1|HID-1 | DNAHL1|DNEL2 | |
| Cytomap | 17q25.1 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein HID1HID1 domain-containing proteinUPF0663 transmembrane protein C17orf28down-regulated in multiple cancers 1downregulated in multiple cancer 1protein hid-1 homolog | dynein heavy chain 17, axonemalaxonemal beta dynein heavy chain 17axonemal dynein heavy chain-like protein 1ciliary dynein heavy chain 17ciliary dynein heavy chain-like protein 1dynein light chain 2, axonemaldynein, axonemal, heavy polypeptide 17 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IV36 | Q9UFH2 | |
| Ensembl transtripts involved in fusion gene | ENST00000425042, ENST00000532900, | ENST00000389840, ENST00000585328, ENST00000586052, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 12 X 12 X 11=1584 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/1584*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HID1 [Title/Abstract] AND DNAH17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HID1 | GO:0006886 | intracellular protein transport | 21337012 |
| Hgene | HID1 | GO:0031001 | response to brefeldin A | 21337012 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-ED-A97K-01A | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000425042 | ENST00000389840 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| In-frame | ENST00000425042 | ENST00000585328 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| 5CDS-intron | ENST00000425042 | ENST00000586052 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| intron-3CDS | ENST00000532900 | ENST00000389840 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| intron-3CDS | ENST00000532900 | ENST00000585328 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
| intron-intron | ENST00000532900 | ENST00000586052 | HID1 | chr17 | 72968686 | - | DNAH17 | chr17 | 76506588 | - |
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FusionProtFeatures for HID1_DNAH17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HID1 | DNAH17 |