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Fusion gene ID: 16158 |
FusionGeneSummary for HHIP_DDX46 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HHIP_DDX46 | Fusion gene ID: 16158 | Hgene | Tgene | Gene symbol | HHIP | DDX46 | Gene ID | 64399 | 9879 |
| Gene name | hedgehog interacting protein | DEAD-box helicase 46 | |
| Synonyms | HIP | PRPF5|Prp5 | |
| Cytomap | 4q31.21 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hedgehog-interacting protein | probable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96QV1 | Q7L014 | |
| Ensembl transtripts involved in fusion gene | ENST00000296575, ENST00000434550, ENST00000511314, | ENST00000452510, ENST00000354283, ENST00000509178, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 6 X 3=90 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HHIP [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HHIP | GO:0009968 | negative regulation of signal transduction | 19561609 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA881233 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000296575 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| 5UTR-intron | ENST00000296575 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| 5UTR-intron | ENST00000296575 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| 5UTR-3CDS | ENST00000434550 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| 5UTR-intron | ENST00000434550 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| 5UTR-intron | ENST00000434550 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| intron-3CDS | ENST00000511314 | ENST00000452510 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| intron-intron | ENST00000511314 | ENST00000354283 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
| intron-intron | ENST00000511314 | ENST00000509178 | HHIP | chr4 | 145567438 | + | DDX46 | chr5 | 134094468 | + |
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FusionProtFeatures for HHIP_DDX46 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HHIP | DDX46 |