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Fusion gene ID: 16148

FusionGeneSummary for HGS_BAIAP2

Fusion gene summary

Fusion gene information	Fusion gene name: HGS_BAIAP2
	Fusion gene ID: 16148
		Hgene	Tgene
	Gene symbol	HGS	BAIAP2
	Gene ID	9146	10458
	Gene name	hepatocyte growth factor-regulated tyrosine kinase substrate	BAI1 associated protein 2
	Synonyms	HRS	BAP2\|FLAF3\|IRSP53
	Cytomap	17q25.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	hepatocyte growth factor-regulated tyrosine kinase substratehuman growth factor-regulated tyrosine kinase substrateprotein pp110	brain-specific angiogenesis inhibitor 1-associated protein 2IRS-58IRSp53/58fas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate protein of 53 kDa
	Modification date	20180522	20180523
	UniProtAcc	O14964	Q9UQB8
	Ensembl transtripts involved in fusion gene	ENST00000329138,	ENST00000392411, ENST00000321280, ENST00000428708, ENST00000575712, ENST00000575245, ENST00000435091, ENST00000321300, ENST00000573894, ENST00000416299,
Fusion gene scores	* DoF score	4 X 5 X 3=60	10 X 7 X 6=420
	# samples	5	10
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/420*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HGS [Title/Abstract] AND BAIAP2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HGS	GO:0046426	negative regulation of JAK-STAT cascade	12444102

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	STAD	TCGA-BR-4357-01A	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000329138	ENST00000392411	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-intron	ENST00000329138	ENST00000321280	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-intron	ENST00000329138	ENST00000428708	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-intron	ENST00000329138	ENST00000575712	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-3UTR	ENST00000329138	ENST00000575245	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-3UTR	ENST00000329138	ENST00000435091	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-3UTR	ENST00000329138	ENST00000321300	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-intron	ENST00000329138	ENST00000573894	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+
5CDS-intron	ENST00000329138	ENST00000416299	HGS	chr17	79658601	+	BAIAP2	chr17	79089570	+

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FusionProtFeatures for HGS_BAIAP2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HGS O14964	BAIAP2 Q9UQB8

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Fusion gene ID: 16148

FusionGeneSummary for HGS_BAIAP2

FusionProtFeatures for HGS_BAIAP2