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Fusion gene ID: 16147 |
FusionGeneSummary for HGSNAT_VSTM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HGSNAT_VSTM2B | Fusion gene ID: 16147 | Hgene | Tgene | Gene symbol | HGSNAT | VSTM2B | Gene ID | 138050 | 342865 |
| Gene name | heparan-alpha-glucosaminide N-acetyltransferase | V-set and transmembrane domain containing 2B | |
| Synonyms | HGNAT|MPS3C|RP73|TMEM76 | - | |
| Cytomap | 8p11.21-p11.1 | 19q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan-alpha-glucosaminide N-acetyltransferasetransmembrane protein 76 | V-set and transmembrane domain-containing protein 2B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q68CP4 | A6NLU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000458501, ENST00000379644, ENST00000297798, ENST00000521576, | ENST00000335523, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 8 X 2 X 6=96 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HGSNAT [Title/Abstract] AND VSTM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HGSNAT | GO:0007041 | lysosomal transport | 20650889 |
| Hgene | HGSNAT | GO:0051259 | protein complex oligomerization | 20650889 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-31-1950-01A | HGSNAT | chr8 | 43037403 | + | VSTM2B | chr19 | 30054753 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000458501 | ENST00000335523 | HGSNAT | chr8 | 43037403 | + | VSTM2B | chr19 | 30054753 | + |
| Frame-shift | ENST00000379644 | ENST00000335523 | HGSNAT | chr8 | 43037403 | + | VSTM2B | chr19 | 30054753 | + |
| Frame-shift | ENST00000297798 | ENST00000335523 | HGSNAT | chr8 | 43037403 | + | VSTM2B | chr19 | 30054753 | + |
| Frame-shift | ENST00000521576 | ENST00000335523 | HGSNAT | chr8 | 43037403 | + | VSTM2B | chr19 | 30054753 | + |
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FusionProtFeatures for HGSNAT_VSTM2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HGSNAT | VSTM2B |