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Fusion gene ID: 16129 |
FusionGeneSummary for HEXB_SSRP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HEXB_SSRP1 | Fusion gene ID: 16129 | Hgene | Tgene | Gene symbol | HEXB | SSRP1 | Gene ID | 3074 | 6749 |
| Gene name | hexosaminidase subunit beta | structure specific recognition protein 1 | |
| Synonyms | ENC-1AS|HEL-248|HEL-S-111 | FACT|FACT80|T160 | |
| Cytomap | 5q13.3 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-hexosaminidase subunit betaHCC-7N-acetyl-beta-glucosaminidase subunit betabeta-N-acetylhexosaminidase subunit betabeta-hexosaminidase beta-subunitcervical cancer proto-oncogene 7 proteinepididymis luminal protein 248epididymis secretory protei | FACT complex subunit SSRP1FACT 80 kDa subunitFACTp80chromatin-specific transcription elongation factor 80 kDa subunitcisplatin-DNA SSRPfacilitates chromatin remodeling 80 kDa subunitfacilitates chromatin transcription complex 80 kDa subunitfacilita | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P07686 | Q08945 | |
| Ensembl transtripts involved in fusion gene | ENST00000511181, ENST00000261416, ENST00000513539, ENST00000509579, | ENST00000278412, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 3=75 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HEXB [Title/Abstract] AND SSRP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA253363 | HEXB | chr5 | 74017013 | - | SSRP1 | chr11 | 57095812 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000511181 | ENST00000278412 | HEXB | chr5 | 74017013 | - | SSRP1 | chr11 | 57095812 | + |
| 3UTR-3CDS | ENST00000261416 | ENST00000278412 | HEXB | chr5 | 74017013 | - | SSRP1 | chr11 | 57095812 | + |
| 3UTR-3CDS | ENST00000513539 | ENST00000278412 | HEXB | chr5 | 74017013 | - | SSRP1 | chr11 | 57095812 | + |
| 3UTR-3CDS | ENST00000509579 | ENST00000278412 | HEXB | chr5 | 74017013 | - | SSRP1 | chr11 | 57095812 | + |
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FusionProtFeatures for HEXB_SSRP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HEXB | SSRP1 |